N-(7-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide

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Chemical Name:N-(7-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide
CAS No.:1173701-43-3
Molecular Formula:C₂₂H₁₆ClF₃N₆O₂
Molecular Weight:488.856
Hs Code.:

Synonyms:N-(7-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide

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Chemical Property of N-(7-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide

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Technology Process of N-(7-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide

There total 7 articles about N-(7-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

: 1173701-33-1
N-(7-(4-aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide

: 327-78-6
4-chloro-3-(trifluoromethyl)phenyl isocyanate

: 1173701-43-3
N-(7-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide

Guidance literature:: In tetrahydrofuran;
DOI:10.1016/j.bmcl.2009.10.051

Reference yield:

: 74895-37-7
2-Cyan-4,4-diethoxybuttersaeurenitril

: 1173701-43-3
N-(7-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: potassium tert-butylate / ethanol / 0 °C / Reflux

2: hydrogenchloride / water / 1.17 h / 50 °C

3: Raney-Nickel / water / 4 h / Reflux

4: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 0 - 80 °C / Inert atmosphere

5: potassium carbonate; copper(l) iodide; L-proline / dimethyl sulfoxide / 40 h / 90 °C / Inert atmosphere

6: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 2585.81 Torr

7: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With hydrogenchloride; copper(l) iodide; palladium on activated charcoal; potassium tert-butylate; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; L-proline; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1248/cpb.c13-00249

Reference yield:

: 370584-51-3
N-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide

: 1173701-43-3
N-(7-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; copper(l) iodide; L-proline / dimethyl sulfoxide / 40 h / 90 °C / Inert atmosphere

2: palladium on activated charcoal; hydrogen / tetrahydrofuran / 2 h / 2585.81 Torr

3: tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With copper(l) iodide; palladium on activated charcoal; hydrogen; potassium carbonate; L-proline; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1248/cpb.c13-00249