benzyl 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(benzyloxycarbonyl)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoate

Base Information

Chemical Name:benzyl 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(benzyloxycarbonyl)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoate
CAS No.:161805-81-8
Molecular Formula:C₄₆H₄₅Cl₂NO₈
Molecular Weight:810.771
Hs Code.:

Synonyms:benzyl 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(benzyloxycarbonyl)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoate

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Chemical Property of benzyl 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(benzyloxycarbonyl)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoate

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Technology Process of benzyl 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(benzyloxycarbonyl)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoate

There total 4 articles about benzyl 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(benzyloxycarbonyl)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40298-71-3,201334-88-5,69541-62-4
N-tert-butoxycarbonyl-O-2,6-dichlorobenzyl-L-tyrosine

: 161805-81-8
benzyl 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(benzyloxycarbonyl)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) isobutyl chloroformate, N-methylmorpholine, 3.) HCl

2: 1.) sodium iodide / 1.) THF, RT, 15 min, 2.) THF, 1 h

3: 1.) sodium hydride / 1.) THF, 2.) THF, RT, 5 h

With 4-methyl-morpholine; hydrogenchloride; sodium hydride; sodium iodide; isobutyl chloroformate;
DOI:10.1021/jm00006a021

Reference yield:

: monosodium salt of dibenzyl malonate

: 161805-81-8
benzyl 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(benzyloxycarbonyl)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) sodium iodide / 1.) THF, RT, 15 min, 2.) THF, 1 h

2: 1.) sodium hydride / 1.) THF, 2.) THF, RT, 5 h

With sodium hydride; sodium iodide;
DOI:10.1021/jm00006a021

Reference yield:

: 161805-77-2
Boc-Tyr(2,6-di-Cl-Bzl)-CH₂Cl

: 161805-81-8
benzyl 5(S)-<(tert-butyloxycarbonyl)amino>-2-benzyl-2-(benzyloxycarbonyl)-6-<4-<<(2,6-dichlorophenyl)methyl>oxy>phenyl>-4-oxohexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) sodium iodide / 1.) THF, RT, 15 min, 2.) THF, 1 h

2: 1.) sodium hydride / 1.) THF, 2.) THF, RT, 5 h

With sodium hydride; sodium iodide;
DOI:10.1021/jm00006a021