ethyl 4-((4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl(propyl)phosphinate

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Chemical Name:ethyl 4-((4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl(propyl)phosphinate
CAS No.:1428526-88-8
Molecular Formula:C₂₆H₂₈N₅O₄P
Molecular Weight:505.513
Hs Code.:

Synonyms:ethyl 4-((4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl(propyl)phosphinate

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Chemical Property of ethyl 4-((4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl(propyl)phosphinate

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Technology Process of ethyl 4-((4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl(propyl)phosphinate

There total 9 articles about ethyl 4-((4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl(propyl)phosphinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187992-96-6
4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxylic acid

: 1428526-87-7
ethyl 4-(amino(phenyl)methyl)phenyl(propyl)phosphinate

: 1428526-88-8
ethyl 4-((4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl(propyl)phosphinate

Guidance literature:: 4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxylic acid; With triethylamine; HATU; In acetonitrile; for 0.0833333h;

ethyl 4-(amino(phenyl)methyl)phenyl(propyl)phosphinate; In acetonitrile; at 20 ℃; for 2h;

Reference yield:

: 90-90-4
(4-bromophenyl)(phenyl)methanone

: 1428526-88-8
ethyl 4-((4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl(propyl)phosphinate

Guidance literature:: Multi-step reaction with 8 steps

1.1: 24 h / 185 °C

2.1: potassium hydroxide / methanol / 8 h / Reflux

3.1: triethylamine / dichloromethane / 0 °C

3.2: 20 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; anilinium hypophosphite; triethylamine / tetrahydrofuran / Reflux; Inert atmosphere

5.1: toluene / Reflux

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

6.2: 2 h / 20 °C / Inert atmosphere

7.1: hydrogenchloride / 1,4-dioxane / 20 °C

8.1: triethylamine; HATU / acetonitrile / 0.08 h

8.2: 2 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; anilinium hypophosphite; triethylamine; HATU; potassium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 55095-17-5,220441-81-6
(4-bromophenyl)(phenyl)methanamine

: 1428526-88-8
ethyl 4-((4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl(propyl)phosphinate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0 °C

1.2: 20 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; anilinium hypophosphite; triethylamine / tetrahydrofuran / Reflux; Inert atmosphere

3.1: toluene / Reflux

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere

4.2: 2 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

6.1: triethylamine; HATU / acetonitrile / 0.08 h

6.2: 2 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; anilinium hypophosphite; triethylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; dichloromethane; toluene; acetonitrile;