(+)-3-hydroxy-2-(2-(methoxycarbonyl)phenylamino)morphinan trifluoroacetate

Base Information

Chemical Name:(+)-3-hydroxy-2-(2-(methoxycarbonyl)phenylamino)morphinan trifluoroacetate
CAS No.:1262869-31-7
Molecular Formula:C₂HF₃O₂*C₂₄H₂₈N₂O₃
Molecular Weight:506.522
Hs Code.:

Synonyms:(+)-3-hydroxy-2-(2-(methoxycarbonyl)phenylamino)morphinan trifluoroacetate

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Chemical Property of (+)-3-hydroxy-2-(2-(methoxycarbonyl)phenylamino)morphinan trifluoroacetate

Chemical Property:

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Technology Process of (+)-3-hydroxy-2-(2-(methoxycarbonyl)phenylamino)morphinan trifluoroacetate

There total 7 articles about (+)-3-hydroxy-2-(2-(methoxycarbonyl)phenylamino)morphinan trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 1262870-17-6
(+)-3-benzyloxy-2-(2-(methoxycarbonyl)phenylamino)-N-(benzyloxycarbonyl)morphinan

: 76-05-1
trifluoroacetic acid

: 1262869-31-7
(+)-3-hydroxy-2-(2-(methoxycarbonyl)phenylamino)morphinan trifluoroacetate

Guidance literature:: (+)-3-benzyloxy-2-(2-(methoxycarbonyl)phenylamino)-N-(benzyloxycarbonyl)morphinan; With boron tribromide; In dichloromethane; at 0 ℃;

With methanol; In dichloromethane;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 15676-23-0
(+)-3-Hydroxymorphinan

: 1262869-31-7
(+)-3-hydroxy-2-(2-(methoxycarbonyl)phenylamino)morphinan trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: nitric acid; formic acid / water / 0 - 20 °C

2: sodium hydroxide / 1,4-dioxane / 0 - 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 70 °C

4: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C

5: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C

6: boron tribromide / dichloromethane / 0 °C

With formic acid; nitric acid; boron tribromide; potassium carbonate; hydrazine hydrate; sodium hydroxide; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: (+)-3-hydroxymorphinan hydrobromide

: 1262869-31-7
(+)-3-hydroxy-2-(2-(methoxycarbonyl)phenylamino)morphinan trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide / 1,4-dioxane; water / 0.5 h / 0 - 20 °C

2: nitric acid; formic acid / water / 0 - 20 °C

3: sodium hydroxide / 1,4-dioxane / 0 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 70 °C

5: hydrazine hydrate / Raney nickel / water; methanol / 2 h / 20 °C

6: sodium t-butanolate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 110 °C

7: boron tribromide / dichloromethane / 0 °C

With formic acid; nitric acid; boron tribromide; potassium carbonate; hydrazine hydrate; sodium hydroxide; sodium t-butanolate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;