7-[N-ethyl-N-2-(tert-butyldimethylsiloxyethyl)aniline-4-yl]-4,4a,5,6-tetrahydro-2(3H)-naphthalenone

Base Information

Chemical Name:7-[N-ethyl-N-2-(tert-butyldimethylsiloxyethyl)aniline-4-yl]-4,4a,5,6-tetrahydro-2(3H)-naphthalenone
CAS No.:548792-51-4
Molecular Formula:C₂₆H₃₉NO₂Si
Molecular Weight:425.687
Hs Code.:

Synonyms:7-[N-ethyl-N-2-(tert-butyldimethylsiloxyethyl)aniline-4-yl]-4,4a,5,6-tetrahydro-2(3H)-naphthalenone

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Chemical Property of 7-[N-ethyl-N-2-(tert-butyldimethylsiloxyethyl)aniline-4-yl]-4,4a,5,6-tetrahydro-2(3H)-naphthalenone

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Technology Process of 7-[N-ethyl-N-2-(tert-butyldimethylsiloxyethyl)aniline-4-yl]-4,4a,5,6-tetrahydro-2(3H)-naphthalenone

There total 3 articles about 7-[N-ethyl-N-2-(tert-butyldimethylsiloxyethyl)aniline-4-yl]-4,4a,5,6-tetrahydro-2(3H)-naphthalenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1614-84-2
(4aSR)-4,4a,5,6-Tetrahydro-7-methoxynaphthalin-2(3H)-on

: 171368-20-0
2-[N-ethyl-N-4-bromophenylamino]-1-tert-butyldimethylsilyloxyethane

: 548792-51-4
7-[N-ethyl-N-2-(tert-butyldimethylsiloxyethyl)aniline-4-yl]-4,4a,5,6-tetrahydro-2(3H)-naphthalenone

Guidance literature:: 2-[N-ethyl-N-4-bromophenylamino]-1-tert-butyldimethylsilyloxyethane; With n-butyllithium; In diethyl ether; hexane; at -10 ℃; for 2h;

(4aSR)-4,4a,5,6-Tetrahydro-7-methoxynaphthalin-2(3H)-on; In diethyl ether; hexane; at 20 ℃; for 2.5h;
DOI:10.1039/b208024a

Reference yield:

: 92-50-2
2-( N-ethylanilino)ethanol

: 548792-51-4
7-[N-ethyl-N-2-(tert-butyldimethylsiloxyethyl)aniline-4-yl]-4,4a,5,6-tetrahydro-2(3H)-naphthalenone

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / N-bromosuccinimide / dimethylformamide / 12 h / 20 °C

2.1: 95 percent / imidazole / dimethylformamide / 2 h

3.1: n-butyllithium / hexane; diethyl ether / 2 h / -10 °C

3.2: 58 percent / hexane; diethyl ether / 2.5 h / 20 °C

With 1H-imidazole; N-Bromosuccinimide; n-butyllithium; In diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1039/b208024a

Reference yield:

: 171368-35-7
1-bromo-4-benzene

: 548792-51-4
7-[N-ethyl-N-2-(tert-butyldimethylsiloxyethyl)aniline-4-yl]-4,4a,5,6-tetrahydro-2(3H)-naphthalenone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / imidazole / dimethylformamide / 2 h

2.1: n-butyllithium / hexane; diethyl ether / 2 h / -10 °C

2.2: 58 percent / hexane; diethyl ether / 2.5 h / 20 °C

With 1H-imidazole; n-butyllithium; In diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1039/b208024a