3-{2-[4-(2-biphenyl)piperazin-1-yl]ethoxy}-N-[(4-trifluoromethylphenyl)methyl]propanamide

Base Information

Chemical Name:3-{2-[4-(2-biphenyl)piperazin-1-yl]ethoxy}-N-[(4-trifluoromethylphenyl)methyl]propanamide
CAS No.:1610849-05-2
Molecular Formula:C₂₉H₃₂F₃N₃O₂
Molecular Weight:511.587
Hs Code.:

Synonyms:3-{2-[4-(2-biphenyl)piperazin-1-yl]ethoxy}-N-[(4-trifluoromethylphenyl)methyl]propanamide

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Chemical Property of 3-{2-[4-(2-biphenyl)piperazin-1-yl]ethoxy}-N-[(4-trifluoromethylphenyl)methyl]propanamide

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Technology Process of 3-{2-[4-(2-biphenyl)piperazin-1-yl]ethoxy}-N-[(4-trifluoromethylphenyl)methyl]propanamide

There total 4 articles about 3-{2-[4-(2-biphenyl)piperazin-1-yl]ethoxy}-N-[(4-trifluoromethylphenyl)methyl]propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1610849-05-2
3-{2-[4-(2-biphenyl)piperazin-1-yl]ethoxy}-N-[(4-trifluoromethylphenyl)methyl]propanamide

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 8h;

In tetrahydrofuran;

Reference yield:

: 3300-51-4
p-Trifluoromethylbenzylamine

: 1610849-32-5
3-[2-[4-(2-biphenyl)piperazin-1-yl]ethoxy]propanoic acid

: 1610849-05-2
3-{2-[4-(2-biphenyl)piperazin-1-yl]ethoxy}-N-[(4-trifluoromethylphenyl)methyl]propanamide

Guidance literature:: 3-[2-[4-(2-biphenyl)piperazin-1-yl]ethoxy]propanoic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃;

p-Trifluoromethylbenzylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/j.ejmech.2016.05.005

Reference yield:

: 180698-18-4
1-([1,1'-biphenyl]-2-yl)piperazine

: 1610849-05-2
3-{2-[4-(2-biphenyl)piperazin-1-yl]ethoxy}-N-[(4-trifluoromethylphenyl)methyl]propanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate; potassium iodide / acetonitrile / 0.17 h / 150 °C / Microwave irradiation

2.1: sodium hydride / tetrahydrofuran / Inert atmosphere

2.2: Inert atmosphere

3.1: hydrogenchloride; water / 1,4-dioxane / 48 h / 20 °C

4.1: 1,1'-carbonyldiimidazole / tetrahydrofuran / 20 °C

4.2: 20 °C

With hydrogenchloride; water; sodium hydride; potassium carbonate; 1,1'-carbonyldiimidazole; potassium iodide; In tetrahydrofuran; 1,4-dioxane; acetonitrile; 2.1: |Michael Addition / 2.2: |Michael Addition;
DOI:10.1016/j.ejmech.2016.05.005