benzyl 4-(2-(N-allyl-2,3,4,5,6-pentafluorophenylsulfonamido)-N-(4-cyclohexylbenzyl)acetamido)-2-(benzyloxy)benzoate

Base Information

Chemical Name:benzyl 4-(2-(N-allyl-2,3,4,5,6-pentafluorophenylsulfonamido)-N-(4-cyclohexylbenzyl)acetamido)-2-(benzyloxy)benzoate
CAS No.:1455006-15-1
Molecular Formula:C₄₅H₄₁F₅N₂O₆S
Molecular Weight:832.888
Hs Code.:

Synonyms:benzyl 4-(2-(N-allyl-2,3,4,5,6-pentafluorophenylsulfonamido)-N-(4-cyclohexylbenzyl)acetamido)-2-(benzyloxy)benzoate

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Chemical Property of benzyl 4-(2-(N-allyl-2,3,4,5,6-pentafluorophenylsulfonamido)-N-(4-cyclohexylbenzyl)acetamido)-2-(benzyloxy)benzoate

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Technology Process of benzyl 4-(2-(N-allyl-2,3,4,5,6-pentafluorophenylsulfonamido)-N-(4-cyclohexylbenzyl)acetamido)-2-(benzyloxy)benzoate

There total 6 articles about benzyl 4-(2-(N-allyl-2,3,4,5,6-pentafluorophenylsulfonamido)-N-(4-cyclohexylbenzyl)acetamido)-2-(benzyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1455006-14-0
benzyl 2-(benzyloxy)-4-(N-(4-cyclohexylbenzyl)-2-(perfluorophenylsulfonamido)acetamido)benzoate

: 106-95-6
allyl bromide

: 1455006-15-1
benzyl 4-(2-(N-allyl-2,3,4,5,6-pentafluorophenylsulfonamido)-N-(4-cyclohexylbenzyl)acetamido)-2-(benzyloxy)benzoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm3017255

Reference yield:

: 1241832-99-4
benzyl 4-amino-2-(benzyloxy)benzoate

: 1455006-15-1
benzyl 4-(2-(N-allyl-2,3,4,5,6-pentafluorophenylsulfonamido)-N-(4-cyclohexylbenzyl)acetamido)-2-(benzyloxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / methanol / 3 h / 45 °C / Molecular sieve; Inert atmosphere

1.2: 45 °C / Inert atmosphere

2.1: dichlorotriphenylphosphorane / chloroform-d1 / 0.25 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

3.1: piperidine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

4.1: potassium carbonate / acetonitrile / 0 - 20 °C / Inert atmosphere; Molecular sieve

5.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With piperidine; potassium carbonate; caesium carbonate; acetic acid; dichlorotriphenylphosphorane; In methanol; chloroform-d1; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3017255

Reference yield:

: 1241833-16-8
benzyl 2-(benzyloxy)-4-((4-cyclohexylbenzyl)amino)benzoate

: 1455006-15-1
benzyl 4-(2-(N-allyl-2,3,4,5,6-pentafluorophenylsulfonamido)-N-(4-cyclohexylbenzyl)acetamido)-2-(benzyloxy)benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichlorotriphenylphosphorane / chloroform-d1 / 0.25 h / 20 °C / Inert atmosphere

1.2: 0.5 h / 110 °C / Inert atmosphere; Microwave irradiation

2.1: piperidine / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

3.1: potassium carbonate / acetonitrile / 0 - 20 °C / Inert atmosphere; Molecular sieve

4.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With piperidine; potassium carbonate; caesium carbonate; dichlorotriphenylphosphorane; In chloroform-d1; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm3017255