4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

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Chemical Name:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate
CAS No.:1362688-86-5
Molecular Formula:C₃₂H₄₉N₆O₈P
Molecular Weight:676.75
Hs Code.:

Synonyms:4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

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Chemical Property of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

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Technology Process of 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

There total 4 articles about 4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₇H₅₇N₆O₁₀P

: 1362688-86-5
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Guidance literature:: C₃₇H₅₇N₆O₁₀P; With phosphoric acid; In chloroform; water; at 20 ℃; for 4.5h;

With water; sodium hydroxide; at 0 - 5 ℃; pH=7;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 13139-16-7
N-(tert-butyloxycarbonyl)-L-isoleucine

: 1362688-86-5
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

2.2: 40 - 50 °C

2.3: 80 - 100 °C

3.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

3.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; dmap; phosphoric acid; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013

Reference yield:

: 15687-27-1,58560-75-1
ibuprofen

: 1362688-86-5
4-{[2-(6-amino-9H-purin-9-yl)ethoxy]methyl}-11-(4-isobutylphenyl)-4-oxido-10-oxo-3,5,9-trioxa-4-phosphadodec-1-yl L-isoleucinate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap; dicyclohexyl-carbodiimide / dichloromethane / 20 °C

2.1: N,N'-dicyclohexyl-4-morpholine carboxamidine / N,N-dimethyl-formamide / 40 - 50 °C

2.2: 40 - 50 °C

2.3: 80 - 100 °C

3.1: phosphoric acid / chloroform; water / 4.5 h / 20 °C

3.2: 0 - 5 °C / pH 7

With N,N'-dicyclohexyl-4-morpholine carboxamidine; dmap; phosphoric acid; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.01.013