(2S,5S)-2-benzyloxycarbonylamino-5-(tert-butoxycarbonylaminomethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester

Base Information

Chemical Name:(2S,5S)-2-benzyloxycarbonylamino-5-(tert-butoxycarbonylaminomethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester
CAS No.:881015-98-1
Molecular Formula:C₅₅H₆₆N₂O₁₁
Molecular Weight:931.136
Hs Code.:

(2S,5S)-2-benzyloxycarbonylamino-5-(tert-butoxycarbonylaminomethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester

Synonyms:(2S,5S)-2-benzyloxycarbonylamino-5-(tert-butoxycarbonylaminomethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester

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Chemical Property of (2S,5S)-2-benzyloxycarbonylamino-5-(tert-butoxycarbonylaminomethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester

Chemical Property:

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Technology Process of (2S,5S)-2-benzyloxycarbonylamino-5-(tert-butoxycarbonylaminomethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester

There total 4 articles about (2S,5S)-2-benzyloxycarbonylamino-5-(tert-butoxycarbonylaminomethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,5S)-5-Aminomethyl-2-benzyloxycarbonylamino-6-((2S,3S,4R,5S,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-hexanoic acid methyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 881015-98-1
(2S,5S)-2-benzyloxycarbonylamino-5-(tert-butoxycarbonylaminomethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; water; at 20 ℃; for 0.5h;
DOI:10.1021/jo052256z

Reference yield:

: 881015-95-8
(2S,5S)-2-benzyloxycarbonylamino-5-(tert-butyldimethylsilanyloxymethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester

: 881015-98-1
(2S,5S)-2-benzyloxycarbonylamino-5-(tert-butoxycarbonylaminomethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 94 percent / TBAF*H₂O / tetrahydrofuran / 0.5 h / 20 °C

2: 93 percent / PPh₃; DEAD; diphenylphosphoryl azide / tetrahydrofuran / 0.25 h / 20 °C

3: PPh₃; H₂O / tetrahydrofuran / 0.25 h / 130 °C / microwave irradiation

4: 106 mg / Et₃N / tetrahydrofuran; H₂O / 0.5 h / 20 °C

With diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; water; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; water; 2: Mitsunobu reaction;
DOI:10.1021/jo052256z

Reference yield:

: 881015-97-0
(2S,5S)-2-benzyloxycarbonylamino-5-(azidomethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester

: 881015-98-1
(2S,5S)-2-benzyloxycarbonylamino-5-(tert-butoxycarbonylaminomethyl)-6-(2,3,4,6-tetra-O-benzyl-β-D-galactopyranosyl)hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: PPh₃; H₂O / tetrahydrofuran / 0.25 h / 130 °C / microwave irradiation

2: 106 mg / Et₃N / tetrahydrofuran; H₂O / 0.5 h / 20 °C

With water; triethylamine; triphenylphosphine; In tetrahydrofuran; water;
DOI:10.1021/jo052256z