3-cyano-2-(2-amino-3-cyano-4-phenylhydrazoacetothionitrilo-6-oxopyridine-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene

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Chemical Name:3-cyano-2-(2-amino-3-cyano-4-phenylhydrazoacetothionitrilo-6-oxopyridine-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene
CAS No.:381719-33-1
Molecular Formula:C₂₃H₁₇N₇OS₂
Molecular Weight:471.566
Hs Code.:

Synonyms:3-cyano-2-(2-amino-3-cyano-4-phenylhydrazoacetothionitrilo-6-oxopyridine-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene

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Chemical Property of 3-cyano-2-(2-amino-3-cyano-4-phenylhydrazoacetothionitrilo-6-oxopyridine-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene

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Technology Process of 3-cyano-2-(2-amino-3-cyano-4-phenylhydrazoacetothionitrilo-6-oxopyridine-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene

There total 4 articles about 3-cyano-2-(2-amino-3-cyano-4-phenylhydrazoacetothionitrilo-6-oxopyridine-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 62-53-3
aniline

: 381719-31-9
3-cyano-2-(2-amino-3-cyano-4-thioacetonitrilo-6-oxopyridine-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophenene

: 381719-33-1
3-cyano-2-(2-amino-3-cyano-4-phenylhydrazoacetothionitrilo-6-oxopyridine-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene

Guidance literature:: aniline; With hydrogenchloride; sodium nitrite; In water; at 0 ℃;

3-cyano-2-(2-amino-3-cyano-4-thioacetonitrilo-6-oxopyridine-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophenene; With sodium hydroxide; In ethanol; water; at 0 ℃; for 3h;
DOI:10.1002/hc.1079

Reference yield:

: 4651-91-6
3-cyano-2-amino-4,5,6,7-tetrahydrobenzo[b]thiophene

: 381719-33-1
3-cyano-2-(2-amino-3-cyano-4-phenylhydrazoacetothionitrilo-6-oxopyridine-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene

Guidance literature:: Multi-step reaction with 5 steps

1.1: 80 percent / 2 h / 140 °C

2.1: 88 percent / Br₂ / acetic acid / 0.17 h / 60 °C

3.1: 66 percent / ethanol / 4 h / 20 °C

4.1: 70 percent / piperidine / dimethylformamide / 5 h / Heating

5.1: sodium nitrite; hydrochloric acid / H₂O / 0 °C

5.2: 81 percent / sodium hydroxide / H₂O; ethanol / 3 h / 0 °C

With piperidine; hydrogenchloride; bromine; sodium nitrite; In ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/hc.1079

Reference yield:

: 381719-12-6
3-cyano-2-(α-oxobutyramido-N-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene

: 381719-33-1
3-cyano-2-(2-amino-3-cyano-4-phenylhydrazoacetothionitrilo-6-oxopyridine-1-yl)-4,5,6,7-tetrahydrobenzo[b]thiophene

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / Br₂ / acetic acid / 0.17 h / 60 °C

2.1: 66 percent / ethanol / 4 h / 20 °C

3.1: 70 percent / piperidine / dimethylformamide / 5 h / Heating

4.1: sodium nitrite; hydrochloric acid / H₂O / 0 °C

4.2: 81 percent / sodium hydroxide / H₂O; ethanol / 3 h / 0 °C

With piperidine; hydrogenchloride; bromine; sodium nitrite; In ethanol; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1002/hc.1079