2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine-6-methyl-(6¹->5')-N⁶-benzoyl-2',3'-O-isopropylideneadenosine

Base Information

• Chemical Name: 2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine-6-methyl-(6¹->5')-N⁶-benzoyl-2',3'-O-isopropylideneadenosine
• CAS No.: 801316-83-6
• Molecular Formula: C₄₂H₅₇N₇O₁₁Si
• Molecular Weight: 864.04

Synonyms:2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine-6-methyl-(6¹->5')-N⁶-benzoyl-2',3'-O-isopropylideneadenosine

Chemical Property of 2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine-6-methyl-(6¹->5')-N⁶-benzoyl-2',3'-O-isopropylideneadenosine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine-6-methyl-(6¹->5')-N⁶-benzoyl-2',3'-O-isopropylideneadenosine

There total 5 articles about 2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine-6-methyl-(6¹->5')-N⁶-benzoyl-2',3'-O-isopropylideneadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

N-6-benzoyl-2',3'-O-isopropylideneadenosine (39947-04-1) + 6-(chloromethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine (582295-66-7) → 2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine-6-methyl-(61->5')-N6-benzoyl-2',3'-O-isopropylideneadenosine (801316-83-6)

Guidance literature:

N-6-benzoyl-2',3'-O-isopropylideneadenosine; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

6-(chloromethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine; In tetrahydrofuran; N,N-dimethyl-formamide; for 2h;

DOI:10.1002/hlca.200490204

Reference yield:

triisopropylsilyl chloride (13154-24-0) → 2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine-6-methyl-(61->5')-N6-benzoyl-2',3'-O-isopropylideneadenosine (801316-83-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 95 percent / 1H-imidazole; DMAP / CH₂Cl₂

2.1: DMAP; MsCl / pyridine / 1 h / 23 °C

2.2: 95 percent / CH₂Cl₂ / pyridine

3.1: NaH / dimethylformamide / 0.5 h / 0 °C

3.2: 62 percent / dimethylformamide; tetrahydrofuran / 2 h

With 1H-imidazole; dmap; sodium hydride; methanesulfonyl chloride; In pyridine; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200490204

Reference yield:

2',3'-O-isopropylideneuridine (362-43-6) → 2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine-6-methyl-(61->5')-N6-benzoyl-2',3'-O-isopropylideneadenosine (801316-83-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 95 percent / 1H-imidazole; DMAP / CH₂Cl₂

2.1: DMAP; MsCl / pyridine / 1 h / 23 °C

2.2: 95 percent / CH₂Cl₂ / pyridine

3.1: NaH / dimethylformamide / 0.5 h / 0 °C

3.2: 62 percent / dimethylformamide; tetrahydrofuran / 2 h

With 1H-imidazole; dmap; sodium hydride; methanesulfonyl chloride; In pyridine; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1002/hlca.200490204

upstream raw materials:

N-6-benzoyl-2',3'-O-isopropylideneadenosine

6-(chloromethyl)-2',3'-O-isopropylidene-5'-O-(triisopropylsilyl)uridine

triisopropylsilyl chloride

2',3'-O-isopropylideneuridine

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