ethyl chloromethylidenecyanoacetate

Base Information

• Chemical Name: ethyl chloromethylidenecyanoacetate
• CAS No.: 1030373-58-0
• Molecular Formula: C₆H₆ClNO₂
• Molecular Weight: 159.572
• Mol file: 1030373-58-0.mol

Synonyms:ethyl chloromethylidenecyanoacetate

Chemical Property of ethyl chloromethylidenecyanoacetate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of ethyl chloromethylidenecyanoacetate

There total 1 articles about ethyl chloromethylidenecyanoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl (ethoxymethylene)cyanoacetate (42466-67-1,42466-69-3) → ethyl chloromethylidenecyanoacetate (1030373-58-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / acetonitrile / 1 h / Inert atmosphere

2: sulfuryl dichloride; N,N-dimethyl-formamide / toluene / Inert atmosphere; Reflux

With sulfuryl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In toluene; acetonitrile;

DOI:10.1002/chem.201605043

Reference yield:

ethyl chloromethylidenecyanoacetate (1030373-58-0) → (E)-2-Cyano-5,5-diphenyl-penta-2,4-dienoic acid ethyl ester (201793-06-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) triethylamine, ether, -20 deg C, 30 min, 2.) benzene, 25 deg C, irradiation or thermolysis

2: 53 percent / diethyl ether / 25 °C

3: 140 °C

In diethyl ether;

DOI:10.1016/0040-4039(81)80120-7

Reference yield:

ethyl chloromethylidenecyanoacetate (1030373-58-0) → 2-Cyano-4,4-diphenyl-bicyclo[1.1.0]butane-2-carboxylic acid ethyl ester (78872-13-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) triethylamine, ether, -20 deg C, 30 min, 2.) benzene, 25 deg C, irradiation or thermolysis

2: 53 percent / diethyl ether / 25 °C

3: 140 °C

In diethyl ether;

DOI:10.1016/0040-4039(81)80120-7

upstream raw materials:

ethyl (ethoxymethylene)cyanoacetate

Downstream raw materials:

(E)-2-Cyano-5,5-diphenyl-penta-2,4-dienoic acid ethyl ester

2-Cyano-4,4-diphenyl-bicyclo[1.1.0]butane-2-carboxylic acid ethyl ester

6-Cyano-4,4-diphenyl-2,3-diaza-bicyclo[3.1.0]hex-2-ene-6-carboxylic acid ethyl ester