Trifluoro-methanesulfonic acid 2-[(furan-2-carbonyl)-methyl-amino]-4-methyl-6-trimethylsilanyl-phenyl ester

Base Information

Chemical Name:Trifluoro-methanesulfonic acid 2-[(furan-2-carbonyl)-methyl-amino]-4-methyl-6-trimethylsilanyl-phenyl ester
CAS No.:1027593-49-2
Molecular Formula:C₁₇H₂₀F₃NO₅SSi
Molecular Weight:435.496
Hs Code.:

Synonyms:Trifluoro-methanesulfonic acid 2-[(furan-2-carbonyl)-methyl-amino]-4-methyl-6-trimethylsilanyl-phenyl ester

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Chemical Property of Trifluoro-methanesulfonic acid 2-[(furan-2-carbonyl)-methyl-amino]-4-methyl-6-trimethylsilanyl-phenyl ester

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Technology Process of Trifluoro-methanesulfonic acid 2-[(furan-2-carbonyl)-methyl-amino]-4-methyl-6-trimethylsilanyl-phenyl ester

There total 9 articles about Trifluoro-methanesulfonic acid 2-[(furan-2-carbonyl)-methyl-amino]-4-methyl-6-trimethylsilanyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 156498-38-3
Furan-2-carboxylic acid (2-hydroxy-5-methyl-3-trimethylsilanyl-phenyl)-methyl-amide

: 1027593-49-2
Trifluoro-methanesulfonic acid 2-[(furan-2-carbonyl)-methyl-amino]-4-methyl-6-trimethylsilanyl-phenyl ester

Guidance literature:: With pyridine; dmap; In dichloromethane; at -20 ℃;
DOI:10.1016/S0040-4039(00)73104-2

Reference yield:

: 2432-14-6
3,5-dibromo-4-hydroxytoluene

: 1027593-49-2
Trifluoro-methanesulfonic acid 2-[(furan-2-carbonyl)-methyl-amino]-4-methyl-6-trimethylsilanyl-phenyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 86 percent / NaNO₂ / acetic acid

2: 60 percent / NaOH / methanol / Heating

3: 82 percent / Na₂S, NaHCO₃ / methanol; H₂O / 0.67 h

4: 72 percent / Et₃N / 0 deg C to RT

5: 87 percent / NaH / tetrahydrofuran

6: 92 percent / BCl₃ / CH₂Cl₂ / -10 °C

7: 100 percent / NaH / tetrahydrofuran

8: 90 percent / t-BuLi / 0.5 h / -78 °C

9: 63 percent / pyridine, DMAP / CH₂Cl₂ / -20 °C

With pyridine; dmap; sodium sulfide; sodium hydroxide; tert.-butyl lithium; boron trichloride; sodium hydride; sodium hydrogencarbonate; triethylamine; sodium nitrite; In tetrahydrofuran; methanol; dichloromethane; water; acetic acid;
DOI:10.1016/S0040-4039(00)73104-2

Reference yield:

: 20039-91-2
2-bromo-4-methyl-6-nitrophenol

: 1027593-49-2
Trifluoro-methanesulfonic acid 2-[(furan-2-carbonyl)-methyl-amino]-4-methyl-6-trimethylsilanyl-phenyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 60 percent / NaOH / methanol / Heating

2: 82 percent / Na₂S, NaHCO₃ / methanol; H₂O / 0.67 h

3: 72 percent / Et₃N / 0 deg C to RT

4: 87 percent / NaH / tetrahydrofuran

5: 92 percent / BCl₃ / CH₂Cl₂ / -10 °C

6: 100 percent / NaH / tetrahydrofuran

7: 90 percent / t-BuLi / 0.5 h / -78 °C

8: 63 percent / pyridine, DMAP / CH₂Cl₂ / -20 °C

With pyridine; dmap; sodium sulfide; sodium hydroxide; tert.-butyl lithium; boron trichloride; sodium hydride; sodium hydrogencarbonate; triethylamine; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1016/S0040-4039(00)73104-2