Technology Process of {2-[(2R,3R,4S,5R,6R)-6-((S)-1-Allyloxy-ethyl)-3,4,5-tris-benzyloxy-tetrahydro-pyran-2-yloxy]-ethyl}-trimethyl-silane
There total 7 articles about {2-[(2R,3R,4S,5R,6R)-6-((S)-1-Allyloxy-ethyl)-3,4,5-tris-benzyloxy-tetrahydro-pyran-2-yloxy]-ethyl}-trimethyl-silane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 9.8 g / silver trifluoromethanesulfonate, s-collidine / CH2Cl2 / 1 h / -28 °C
2: sodium methoxide / methanol / 16 h
3: sodium hydride / dimethylformamide / 2 h
With
2,4,6-trimethyl-pyridine; sodium methylate; silver trifluoromethanesulfonate; sodium hydride;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00084a003
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 4-(N,N-dimethylamino)pyridine, pyridine / 16 h
2: 1.) acetic acid, hydrazine, 2.) Vilsmeier bromide, s-collidine / 1.) DMF, 50 deg C, 2 h, 2.) CH2Cl2, 2 h
3: 9.8 g / silver trifluoromethanesulfonate, s-collidine / CH2Cl2 / 1 h / -28 °C
4: sodium methoxide / methanol / 16 h
5: sodium hydride / dimethylformamide / 2 h
With
pyridine; 2,4,6-trimethyl-pyridine; dmap; Vilsmeier bromide; sodium methylate; silver trifluoromethanesulfonate; sodium hydride; acetic acid; hydrazine;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00084a003
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 90percent aq. trifluoroacetic acid / CH2Cl2 / 1 h / 0 °C
2: 4-(N,N-dimethylamino)pyridine, pyridine / 16 h
3: 1.) acetic acid, hydrazine, 2.) Vilsmeier bromide, s-collidine / 1.) DMF, 50 deg C, 2 h, 2.) CH2Cl2, 2 h
4: 9.8 g / silver trifluoromethanesulfonate, s-collidine / CH2Cl2 / 1 h / -28 °C
5: sodium methoxide / methanol / 16 h
6: sodium hydride / dimethylformamide / 2 h
With
pyridine; 2,4,6-trimethyl-pyridine; dmap; Vilsmeier bromide; sodium methylate; silver trifluoromethanesulfonate; sodium hydride; acetic acid; trifluoroacetic acid; hydrazine;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja00084a003
