trans-8-chloro-1-(4-phenoxycyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

Base Information

Chemical Name:trans-8-chloro-1-(4-phenoxycyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester
CAS No.:1228087-62-4
Molecular Formula:C₂₇H₃₁ClN₄O₃
Molecular Weight:495.021
Hs Code.:

Synonyms:trans-8-chloro-1-(4-phenoxycyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

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Chemical Property of trans-8-chloro-1-(4-phenoxycyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

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Technology Process of trans-8-chloro-1-(4-phenoxycyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

There total 9 articles about trans-8-chloro-1-(4-phenoxycyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1226807-97-1
7-chloro-2-thioxo-1,2,3,5-tetrahydrobenzo[e][1,4]diazepine-4-carboxylic acid tert-butyl ester

: 1228087-29-3
trans-4-(phenoxy)cyclohexanecarboxylic acid hydrazide

: 1228087-62-4
trans-8-chloro-1-(4-phenoxycyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

Guidance literature:: In butan-1-ol; Reflux;

Reference yield:

: 1228086-96-1
trans-4-(phenoxy)cyclohexanecarboxylic acid methyl ester

: 1228087-62-4
trans-8-chloro-1-(4-phenoxycyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: hydrazine hydrate / 5 h / 120 °C

2: butan-1-ol / Reflux

With hydrazine hydrate; In butan-1-ol;
DOI:10.1021/acs.jmedchem.9b01478

Reference yield:

: 73033-58-6
5-chloro-2-nitrobenzyl alcohol

: 1228087-62-4
trans-8-chloro-1-(4-phenoxycyclohexyl)-4H,6H-2,3,5,10b-tetraaza-benzo[e]azulene-5-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride; triethylamine / dichloromethane / 3.5 h / 24 - 32 °C

2.1: triethylamine / ethanol / 8 h / Reflux

3.1: dmap / dichloromethane / 18 h / 0 - 20 °C

4.1: zinc dibromide / ethyl acetate / 0.25 h / Inert atmosphere

4.2: 48 h / 20 °C / 750.08 Torr

5.1: potassium tert-butylate / tetrahydrofuran / 3 h / 5 - 20 °C

6.1: Lawessons reagent / tetrahydrofuran / 3 h / Reflux

7.1: butan-1-ol / Reflux

With Lawessons reagent; dmap; thionyl chloride; potassium tert-butylate; triethylamine; zinc dibromide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; butan-1-ol;
DOI:10.1021/acs.jmedchem.9b01478