2-(3-Amino-1,2-oxazol-5-yl)-2-methylpropan-1-ol

Base Information

Chemical Name:2-(3-Amino-1,2-oxazol-5-yl)-2-methylpropan-1-ol
CAS No.:86860-67-5
Molecular Formula:C7H12 N2 O2
Molecular Weight:156.184
Hs Code.:
European Community (EC) Number:826-988-0
DSSTox Substance ID:DTXSID40695696
Wikidata:Q82624958
Mol file:86860-67-5.mol

Synonyms:86860-67-5;2-(3-amino-1,2-oxazol-5-yl)-2-methylpropan-1-ol;2-(3-AMINOISOXAZOL-5-YL)-2-METHYLPROPAN-1-OL;2-(3-Amino-5-isoxazolyl)-2-methyl-1-propanol;SCHEMBL769601;DTXSID40695696;YCOAZGLRGGYBTB-UHFFFAOYSA-N;MFCD18642380;AKOS006373283;SY288605;2-(3-Aminoisoxazol-5-Yl)-2-Methylpropanol;FT-0758961;EN300-1827316;Z1198729704

Suppliers and Price of 2-(3-Amino-1,2-oxazol-5-yl)-2-methylpropan-1-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of 2-(3-Amino-1,2-oxazol-5-yl)-2-methylpropan-1-ol

Chemical Property:

Boiling Point:324.3±32.0 °C(Predicted)
PKA:14.32±0.10(Predicted)
PSA：73.01000
Density:1.183±0.06 g/cm3(Predicted)
LogP:0.45680
XLogP3:0.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:156.089877630
Heavy Atom Count:11
Complexity:138

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(CO)C1=CC(=NO1)N

Technology Process of 2-(3-Amino-1,2-oxazol-5-yl)-2-methylpropan-1-ol

There total 4 articles about 2-(3-Amino-1,2-oxazol-5-yl)-2-methylpropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 489432-33-9
5-hydroxy-4,4-dimethyl-3-oxo-pentanenitrile

: 86860-67-5
2-(3-aminoisoxazol-5-yl)-2-methylpropan-1-ol

Guidance literature:: 5-hydroxy-4,4-dimethyl-3-oxo-pentanenitrile; With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; at 60 ℃; for 22h;

With hydrogenchloride; In ethanol; water; at 20 - 80 ℃;

With sodium hydroxide; In ethanol; water;

Reference yield:

: 14002-80-3
Methyl 2,2-dimethyl-3-hydroxypropionate

: 86860-67-5
2-(3-aminoisoxazol-5-yl)-2-methylpropan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 15.75 h / 70 - 75 °C

3.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 22 h / 60 °C

3.2: 1 h / 80 °C

With hydroxylamine hydrochloride; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm2009925

Reference yield:

: 14002-73-4
3-hydroxy-2,2-dimethyl-propionic acid ethyl ester

: 86860-67-5
2-(3-aminoisoxazol-5-yl)-2-methylpropan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 15 h / 75 °C

2.1: hydroxylamine sulfate; sodium hydroxide / water; methanol / 80 °C

2.2: 80 °C

With sodium hydride; hydroxylamine sulfate; sodium hydroxide; In tetrahydrofuran; methanol; water;
DOI:10.1016/j.bmcl.2015.07.023