1-[(1S,9aR)-octahydro-2H-quinolizin-1-yl]-3-phenylpropan-2-one

Base Information

• Chemical Name: 1-[(1S,9aR)-octahydro-2H-quinolizin-1-yl]-3-phenylpropan-2-one
• CAS No.: 702638-67-3
• Molecular Formula: C₁₈H₂₅NO
• Molecular Weight: 271.403
• Mol file: 702638-67-3.mol

Synonyms:1-[(1S,9aR)-octahydro-2H-quinolizin-1-yl]-3-phenylpropan-2-one

Chemical Property of 1-[(1S,9aR)-octahydro-2H-quinolizin-1-yl]-3-phenylpropan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(1S,9aR)-octahydro-2H-quinolizin-1-yl]-3-phenylpropan-2-one

There total 1 articles about 1-[(1S,9aR)-octahydro-2H-quinolizin-1-yl]-3-phenylpropan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.6%

(1S,9aR)-octahydro-2H-quinolizine-1-acetonitrile (5176-10-3) + benzylmagnesium chloride (6921-34-2) → 1-[(1S,9aR)-octahydro-2H-quinolizin-1-yl]-3-phenylpropan-2-one (702638-67-3)

Guidance literature:

In diethyl ether; for 11h; Heating;

DOI:10.1002/hlca.200490055

Reference yield: 80.0%

1-[(1S,9aR)-octahydro-2H-quinolizin-1-yl]-3-phenylpropan-2-one (702638-67-3) → (1R,9aR)-octahydro-1-(3-phenylpropyl)-2H-quinolizine

Guidance literature:

With sodium; hydrazine hydrate; In diethylene glycol; at 205 - 210 ℃; for 4h;

DOI:10.1002/hlca.200490055

Reference yield: 80.0%

1-[(1S,9aR)-octahydro-2H-quinolizin-1-yl]-3-phenylpropan-2-one (702638-67-3) → (1S,9aR)-octahydro-α-(phenylmethyl)-2H-quinolizine-1-ethanol

Guidance literature:

1-[(1S,9aR)-octahydro-2H-quinolizin-1-yl]-3-phenylpropan-2-one; With toluene-4-sulfonic acid hydrazide; In methanol; for 3.5h; Heating;

With sodium tetrahydroborate; In methanol; for 3h; Heating;

DOI:10.1002/hlca.200490055

upstream raw materials:

(1S,9aR)-octahydro-2H-quinolizine-1-acetonitrile

benzylmagnesium chloride