(S)-1-[(S)-2-(2-aminooxy-ethyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-methoxy-propan-1-one hydrochloride

Base Information

Chemical Name:(S)-1-[(S)-2-(2-aminooxy-ethyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-methoxy-propan-1-one hydrochloride
CAS No.:1018690-05-5
Molecular Formula:C₂₀H₂₁F₂N₃O₃S*ClH
Molecular Weight:457.929
Hs Code.:

Synonyms:(S)-1-[(S)-2-(2-aminooxy-ethyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-methoxy-propan-1-one hydrochloride

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Chemical Property of (S)-1-[(S)-2-(2-aminooxy-ethyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-methoxy-propan-1-one hydrochloride

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Technology Process of (S)-1-[(S)-2-(2-aminooxy-ethyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-methoxy-propan-1-one hydrochloride

There total 3 articles about (S)-1-[(S)-2-(2-aminooxy-ethyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-methoxy-propan-1-one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1018690-28-2
C₂₅H₂₉F₂N₃O₅S

: 1018690-05-5
(S)-1-[(S)-2-(2-aminooxy-ethyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-methoxy-propan-1-one hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 4h;

Reference yield:

: 1021853-64-4
C₇H₄F₂S₂

: 1018690-05-5
(S)-1-[(S)-2-(2-aminooxy-ethyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-methoxy-propan-1-one hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / water / 14 h / 20 °C

2: sodium hydroxide; hydrazine / 14 h / 0 - 20 °C

3: ethanol / 16 h / 20 °C

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / 16 h / 20 °C

5: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; hydrazine; In 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1018690-26-0
tert-butyl 3-oxo-3-phenyl-propoxycarbamate

: 1018690-05-5
(S)-1-[(S)-2-(2-aminooxy-ethyl)-5-(2,5-difluoro-phenyl)-2-phenyl-[1,3,4]thiadiazol-3-yl]-2-methoxy-propan-1-one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 16 h / 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane; N,N-dimethyl-formamide / 16 h / 20 °C

3: hydrogenchloride / 1,4-dioxane / 4 h / 20 °C

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide;