methyl (3R)-3-(2,3-dihydro-1H-indol-1-yl)-3-phenylpropylcarbamate

Base Information

• Chemical Name: methyl (3R)-3-(2,3-dihydro-1H-indol-1-yl)-3-phenylpropylcarbamate
• CAS No.: 1036637-51-0
• Molecular Formula: C₁₉H₂₂N₂O₂
• Molecular Weight: 310.396
• Mol file: 1036637-51-0.mol

Synonyms:methyl (3R)-3-(2,3-dihydro-1H-indol-1-yl)-3-phenylpropylcarbamate

Chemical Property of methyl (3R)-3-(2,3-dihydro-1H-indol-1-yl)-3-phenylpropylcarbamate

Chemical Property:

Purity/Quality:

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Technology Process of methyl (3R)-3-(2,3-dihydro-1H-indol-1-yl)-3-phenylpropylcarbamate

There total 1 articles about methyl (3R)-3-(2,3-dihydro-1H-indol-1-yl)-3-phenylpropylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(3R)-3-(2,3-dihydro-1H-indol-1-yl)-3-phenylpropylamine (1036637-50-9) + methyl chloroformate (79-22-1) → methyl (3R)-3-(2,3-dihydro-1H-indol-1-yl)-3-phenylpropylcarbamate (1036637-51-0)

Guidance literature:

With potassium carbonate; In dichloromethane; water; at 0 - 20 ℃; for 0.5h; optical yield given as %ee;

DOI:10.1021/ol8009286

Reference yield: 100.0%

methyl (3R)-3-(2,3-dihydro-1H-indol-1-yl)-3-phenylpropylcarbamate (1036637-51-0) → (3R)-3-(2,3-dihydro-1H-indol-1-yl)-N-methyl-3-phenylpropan-1-amine (1036637-52-1)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; optical yield given as %ee; Reflux; Inert atmosphere;

DOI:10.1021/ol8009286

upstream raw materials:

(3R)-3-(2,3-dihydro-1H-indol-1-yl)-3-phenylpropylamine

methyl chloroformate

Downstream raw materials:

(3R)-3-(2,3-dihydro-1H-indol-1-yl)-N-methyl-3-phenylpropan-1-amine