3-(2-(5-cyclohexylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

Base Information

Chemical Name:3-(2-(5-cyclohexylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine
CAS No.:1308869-08-0
Molecular Formula:C₂₉H₃₁N₃
Molecular Weight:421.585
Hs Code.:

Synonyms:3-(2-(5-cyclohexylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

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Chemical Property of 3-(2-(5-cyclohexylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

Chemical Property:

Purity/Quality:

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Technology Process of 3-(2-(5-cyclohexylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

There total 12 articles about 3-(2-(5-cyclohexylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1308869-07-9
3-(2-(5-cyclohexenylpyridin-3-yl)vinyl)-6-o-tolylquinolin-2-amine

: 1308869-08-0
3-(2-(5-cyclohexylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; dichloromethane; for 12h; Inert atmosphere;

Reference yield:

: 89490-05-1,21190-87-4
cyclohex-1-enylboronic acid

: 1308869-08-0
3-(2-(5-cyclohexylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / ethanol; water / 18 h / 80 °C / Inert atmosphere

2: potassium carbonate / dimethyl sulfoxide / 1 h / 70 °C

3: 1-methyl-pyrrolidin-2-one / 0.5 h / 200 °C / Microwave irradiation

4: trifluoroacetic acid / 1 h / 90 °C

5: potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / ethanol; water / 2 h / 100 °C

6: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 12 h / Inert atmosphere

With hydrogen; potassium acetate; potassium carbonate; trifluoroacetic acid; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 948290-77-5
6-bromo-2-chloro-3-(chloromethyl)quinoline

: 1308869-08-0
3-(2-(5-cyclohexylpyridin-3-yl)ethyl)-6-o-tolylquinolin-2-amine

Guidance literature:: Multi-step reaction with 6 steps

1: toluene / 12 h / Reflux

2: potassium carbonate / dimethyl sulfoxide / 1 h / 70 °C

3: 1-methyl-pyrrolidin-2-one / 0.5 h / 200 °C / Microwave irradiation

4: trifluoroacetic acid / 1 h / 90 °C

5: potassium acetate / bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II) / ethanol; water / 2 h / 100 °C

6: hydrogen / palladium 10% on activated carbon / dichloromethane; ethanol / 12 h / Inert atmosphere

With hydrogen; potassium acetate; potassium carbonate; trifluoroacetic acid; bis(di-tert-?butyl(4-?dimethylaminophenyl)?phosphine)?dichloropalladium(II); palladium 10% on activated carbon; In 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; dimethyl sulfoxide; toluene;