(5R,6S,E)-isopropyl 5-(dibenzylamino)-8-ethyl-6-hydroxy-2,2-dimethoxydec-3-enoate

Base Information

• Chemical Name: (5R,6S,E)-isopropyl 5-(dibenzylamino)-8-ethyl-6-hydroxy-2,2-dimethoxydec-3-enoate
• CAS No.: 1254212-48-0
• Molecular Formula: C₃₁H₄₅NO₅
• Molecular Weight: 511.702
• Mol file: 1254212-48-0.mol

Synonyms:(5R,6S,E)-isopropyl 5-(dibenzylamino)-8-ethyl-6-hydroxy-2,2-dimethoxydec-3-enoate

Chemical Property of (5R,6S,E)-isopropyl 5-(dibenzylamino)-8-ethyl-6-hydroxy-2,2-dimethoxydec-3-enoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5R,6S,E)-isopropyl 5-(dibenzylamino)-8-ethyl-6-hydroxy-2,2-dimethoxydec-3-enoate

There total 1 articles about (5R,6S,E)-isopropyl 5-(dibenzylamino)-8-ethyl-6-hydroxy-2,2-dimethoxydec-3-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-4-ethyl-2-hydroxyhexanal (1254212-39-9) + (E)-4-isopropoxy-3,3-dimethoxy-4-oxobut-1-enylboronic acid (1254212-34-4) + dibenzylamine (103-49-1) → (5R,6S,E)-isopropyl 5-(dibenzylamino)-8-ethyl-6-hydroxy-2,2-dimethoxydec-3-enoate (1254212-48-0)

Guidance literature:

at 120 ℃; for 2h; Microwave irradiation;

DOI:10.1021/ol102326b

Reference yield: 5.0%

(5R,6S,E)-isopropyl 5-(dibenzylamino)-8-ethyl-6-hydroxy-2,2-dimethoxydec-3-enoate (1254212-48-0) → (5R,6S,Z)-isopropyl 5-(dibenzylamino)-6-(2-ethylbutyl)-2-methoxy-5,6-dihydro-2H-pyran-2-carboxylate (1254212-51-5) + (5R,6S,Z)-isopropyl 5-(dibenzylamino)-6-(2-ethylbutyl)-2-hydroxy-5,6-dihydro-2H-pyran-2-carboxylate + (5R,6S,Z)-isopropyl 5-(dibenzylamino)-6-(2-ethylbutyl)-2-hydroxy-5,6-dihydro-2H-pyran-2-carboxylate

Guidance literature:

With iron(III) chloride hexahydrate; In dichloromethane; at 20 ℃; for 113h; optical yield given as %de;

DOI:10.1021/ol102326b

upstream raw materials:

(S)-4-ethyl-2-hydroxyhexanal

(E)-4-isopropoxy-3,3-dimethoxy-4-oxobut-1-enylboronic acid

dibenzylamine

Downstream raw materials:

(5R,6S,Z)-isopropyl 5-(dibenzylamino)-6-(2-ethylbutyl)-2-methoxy-5,6-dihydro-2H-pyran-2-carboxylate