(+/-)-2-benzyloxymethyl-2-(4-methoxybenzyloxymethyl)oxirane

Base Information

• Chemical Name: (+/-)-2-benzyloxymethyl-2-(4-methoxybenzyloxymethyl)oxirane
• CAS No.: 1201901-80-5
• Molecular Formula: C₁₉H₂₂O₄
• Molecular Weight: 314.381
• Mol file: 1201901-80-5.mol

Synonyms:(+/-)-2-benzyloxymethyl-2-(4-methoxybenzyloxymethyl)oxirane

Chemical Property of (+/-)-2-benzyloxymethyl-2-(4-methoxybenzyloxymethyl)oxirane

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (+/-)-2-benzyloxymethyl-2-(4-methoxybenzyloxymethyl)oxirane

There total 2 articles about (+/-)-2-benzyloxymethyl-2-(4-methoxybenzyloxymethyl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

trimethylsulfoxonium iodide (1774-47-6) + 1-benzyloxy-3-(4-methoxybenzyloxy)propan-2-one (213122-44-2) → (+/-)-2-benzyloxymethyl-2-(4-methoxybenzyloxymethyl)oxirane (1201901-80-5)

Guidance literature:

trimethylsulfoxonium iodide; With n-butyllithium; tetrabutylammomium bromide; In hexane; dimethyl sulfoxide; at 20 ℃; for 0.5h; Inert atmosphere;

1-benzyloxy-3-(4-methoxybenzyloxy)propan-2-one; In hexane; dimethyl sulfoxide; at 20 ℃; for 0.416667h; Inert atmosphere;

DOI:10.1016/j.tetasy.2010.07.014

Reference yield: 79.0%

1-(2-benzyloxymethylallyloxymethyl)-4-methoxybenzene (1201901-79-2) → (+/-)-2-benzyloxymethyl-2-(4-methoxybenzyloxymethyl)oxirane (1201901-80-5)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; water; Reflux;

DOI:10.1016/j.tet.2009.09.106

Reference yield: 91.0%

(+/-)-2-benzyloxymethyl-2-(4-methoxybenzyloxymethyl)oxirane (1201901-80-5) → (+/-)-2-benzyloxymethyl-2-hydroxymethyloxirane (1201901-47-4)

Guidance literature:

With tetrabutylammomium bromide; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 20 ℃; for 3h; aq. phosphate buffer;

DOI:10.1016/j.tetasy.2010.07.014

upstream raw materials:

1-(2-benzyloxymethylallyloxymethyl)-4-methoxybenzene

trimethylsulfoxonium iodide

1-benzyloxy-3-(4-methoxybenzyloxy)propan-2-one

Downstream raw materials:

3-benzyloxymethyl-3-hydroxy-4-(4-methoxybenzyloxy)butyronitrile

(+/-)-2-benzyloxymethyl-2-hydroxymethyloxirane