(E)-N-benzyl-N-(1-bromo-2-(4-cyanophenyl)vinyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:(E)-N-benzyl-N-(1-bromo-2-(4-cyanophenyl)vinyl)-4-methylbenzenesulfonamide
CAS No.:1422721-72-9
Molecular Formula:C₂₃H₁₉BrN₂O₂S
Molecular Weight:467.386
Hs Code.:

Synonyms:(E)-N-benzyl-N-(1-bromo-2-(4-cyanophenyl)vinyl)-4-methylbenzenesulfonamide

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Chemical Property of (E)-N-benzyl-N-(1-bromo-2-(4-cyanophenyl)vinyl)-4-methylbenzenesulfonamide

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Technology Process of (E)-N-benzyl-N-(1-bromo-2-(4-cyanophenyl)vinyl)-4-methylbenzenesulfonamide

There total 4 articles about (E)-N-benzyl-N-(1-bromo-2-(4-cyanophenyl)vinyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1228672-40-9
4-(2-(N-benzyl-N-tosylamino)ethynyl)benzonitrile

: 1422721-72-9
(E)-N-benzyl-N-(1-bromo-2-(4-cyanophenyl)vinyl)-4-methylbenzenesulfonamide

Guidance literature:: 4-(2-(N-benzyl-N-tosylamino)ethynyl)benzonitrile; With trimethylsilyl bromide; In dichloromethane; at -78 ℃; for 0.333333h; Inert atmosphere;

With water; In dichloromethane; at -78 - 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.tetlet.2012.12.101

Reference yield:

: 1576-37-0
N-benzyl-p-toluenesulfonamide

: 1422721-72-9
(E)-N-benzyl-N-(1-bromo-2-(4-cyanophenyl)vinyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate; copper(II) sulphate hydrate; 1,10-Phenanthroline / toluene / 15 h / 80 °C / Inert atmosphere

2.1: trimethylsilyl bromide / dichloromethane / 0.33 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 - 0 °C / Inert atmosphere

With potassium phosphate; 1,10-Phenanthroline; copper(II) sulphate hydrate; trimethylsilyl bromide; In dichloromethane; toluene;
DOI:10.1016/j.tetlet.2012.12.101

Reference yield:

: 3032-92-6
4-cyanophenylacetylene

: 1422721-72-9
(E)-N-benzyl-N-(1-bromo-2-(4-cyanophenyl)vinyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-Bromosuccinimide; silver nitrate / acetone / 2 h / 20 °C / Inert atmosphere

2.1: potassium phosphate; copper(II) sulphate hydrate; 1,10-Phenanthroline / toluene / 15 h / 80 °C / Inert atmosphere

3.1: trimethylsilyl bromide / dichloromethane / 0.33 h / -78 °C / Inert atmosphere

3.2: 1 h / -78 - 0 °C / Inert atmosphere

With potassium phosphate; N-Bromosuccinimide; 1,10-Phenanthroline; copper(II) sulphate hydrate; trimethylsilyl bromide; silver nitrate; In dichloromethane; acetone; toluene;
DOI:10.1016/j.tetlet.2012.12.101