exo (5R,6R)-6-(3-(3-phenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

Base Information

• Chemical Name: exo (5R,6R)-6-(3-(3-phenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane
• CAS No.: 215182-97-1
• Molecular Formula: C₁₈H₁₉N₃S₂
• Molecular Weight: 341.501
• Mol file: 215182-97-1.mol

Synonyms:exo (5R,6R)-6-(3-(3-phenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

Chemical Property of exo (5R,6R)-6-(3-(3-phenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of exo (5R,6R)-6-(3-(3-phenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane

There total 3 articles about exo (5R,6R)-6-(3-(3-phenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-phenyl-2-propyn-1-yl methanesulfonate (82490-61-7) + exo (5R,6R)-6-(3-propylsulfonyl-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane → exo (5R,6R)-6-(3-(3-phenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane (215182-97-1)

Guidance literature:

exo (5R,6R)-6-(3-propylsulfonyl-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane; With sodium hydrogensulfide; In DMF (N,N-dimethyl-formamide); at 100 ℃; for 3h; Heating / reflux;

3-phenyl-2-propyn-1-yl methanesulfonate; With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 4h;

Reference yield:

exo (5R,6R)-6-(3-propylsulfonyl-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane → exo (5R,6R)-6-(3-(3-phenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane (215182-97-1)

Guidance literature:

Multi-step reaction with 2 steps

1: NaSH*H₂O / dimethylformamide / 3 h / 100 °C

2: K₂CO₃ / dimethylformamide / 4 h / Ambient temperature

With sodium hydrogensulfide; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(98)00509-5

Reference yield:

3-phenyl-2-propyn-1-yl methanesulfonate (82490-61-7) + (5R,6R)-4-(1-Aza-bicyclo[3.2.1]oct-6-yl)-[1,2,5]thiadiazole-3-thiol → exo (5R,6R)-6-(3-(3-phenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl)-1-azabicyclo[3.2.1]octane (215182-97-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 4h; Ambient temperature;

DOI:10.1016/S0960-894X(98)00509-5

upstream raw materials:

3-phenyl-2-propyn-1-yl methanesulfonate