4-[2-phenyl-4-(pyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl]aniline

Base Information

Chemical Name:4-[2-phenyl-4-(pyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl]aniline
CAS No.:1283092-19-2
Molecular Formula:C₂₆H₃₀N₄OSi
Molecular Weight:442.636
Hs Code.:

Synonyms:4-[2-phenyl-4-(pyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl]aniline

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Chemical Property of 4-[2-phenyl-4-(pyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl]aniline

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Technology Process of 4-[2-phenyl-4-(pyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl]aniline

There total 5 articles about 4-[2-phenyl-4-(pyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl]aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1283092-18-1
4-[5-(4-nitrophenyl)-2-phenyl-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-4-yl]pyridine

: 1283092-19-2
4-[2-phenyl-4-(pyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl]aniline

Guidance literature:: With ammonium formate; 5%-palladium/activated carbon; In ethanol; at 60 ℃; for 4h;

Reference yield:

: 234766-97-3
4-(2-phenyl-1H-imidazol-4-yl)pyridine

: 1283092-19-2
4-[2-phenyl-4-(pyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl]aniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; oil / 0.5 h / 0 °C

1.2: 0 - 20 °C

2.1: bromine; sodium carbonate / dichloromethane; water / 0.67 h / 20 °C

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

4.1: ammonium formate / 5%-palladium/activated carbon / ethanol / 4 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; ammonium formate; sodium hydride; sodium carbonate; 5%-palladium/activated carbon; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; oil;

Reference yield:

: 405554-89-4
4-(5-bromo-2-phenyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)pyridine

: 1283092-19-2
4-[2-phenyl-4-(pyridin-4-yl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-5-yl]aniline

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,2-dimethoxyethane; water / 16 h / 90 °C / Inert atmosphere

2: ammonium formate / 5%-palladium/activated carbon / ethanol / 4 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; ammonium formate; sodium carbonate; 5%-palladium/activated carbon; In 1,2-dimethoxyethane; ethanol; water;