Technology Process of 6-(4-Methylphenyl)-picolinic acid
There total 10 articles about 6-(4-Methylphenyl)-picolinic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
6-bromo-pyridine-2-carboxylic acid; 4-methylphenylboronic acid;
With
sodium hydrogencarbonate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; water;
at 100 ℃;
for 2h;
Microwave;
With
hydrogenchloride;
In
water;
pH=1;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) 17percent ethanolic NH3, 2.) concd. HCl / 1.) from 100 deg C to 110 deg C, 18 h, 2.) reflux, 18 h
2: SOCl2 / 5 h / Heating
3: Heating
4: H2, 10percent HCl / 10percent Pd/C / methanol / 22 h / 760 Torr
5: 5percent methanolic KOH / 1 h / Ambient temperature
With
hydrogenchloride; potassium hydroxide; thionyl chloride; ammonia; hydrogen;
palladium on activated charcoal;
In
methanol;
DOI:10.1021/jm00364a026
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 30percent aq. H2O2 / acetic acid / 20 h / 80 °C
2: 1.) Me2SO4 / 1.) 80-90 deg C, 2 h, 2.) dioxane, H2O, RT, 30 min
3: 5 M aq. HCl / 11 h / Heating
4: SOCl2 / 1 h / Heating
5: Heating
6: H2, 10percent HCl / 10percent Pd/C / methanol / 22 h / 760 Torr
7: 5percent methanolic KOH / 1 h / Ambient temperature
With
hydrogenchloride; potassium hydroxide; thionyl chloride; hydrogen; dihydrogen peroxide; dimethyl sulfate;
palladium on activated charcoal;
In
methanol; acetic acid;
DOI:10.1021/jm00364a026