6-(2-Methoxyphenyl)picolinic acid

Base Information

• Chemical Name: 6-(2-Methoxyphenyl)picolinic acid
• CAS No.: 86696-69-7
• Molecular Formula: C13H11 N O3
• Molecular Weight: 229.23
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID40509789
• Wikidata: Q82367652
• Mol file: 86696-69-7.mol

Synonyms:6-(2-Methoxyphenyl)picolinic acid;86696-69-7;6-(2-Methoxyphenyl)pyridine-2-carboxylic acid;6-(2-Methoxyphenyl)picolinicacid;DTXSID40509789;AKOS016013174;AB23980;TS-03259;CS-0038246;W12075;A916106;Z2581547792

Chemical Property of 6-(2-Methoxyphenyl)picolinic acid

Chemical Property:

• PSA: 59.42000
• LogP: 2.45540
• Storage Temp.: 2-8°C
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 229.07389321
• Heavy Atom Count: 17
• Complexity: 269

Purity/Quality:

98%min ^*data from raw suppliers

6-(2-Methoxyphenyl)pyridine-2-carboxylic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1C2=NC(=CC=C2)C(=O)O

Technology Process of 6-(2-Methoxyphenyl)picolinic acid

There total 3 articles about 6-(2-Methoxyphenyl)picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-pyridine-2-carboxylic acid (21190-87-4) + 2-Methoxyphenylboronic acid (5720-06-9) → 6-(2-Methoxy-phenyl)-pyridine-2-carboxylic acid (86696-69-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; for 12h; Inert atmosphere; Schlenk technique; Reflux;

DOI:10.1246/bcsj.20190134

Reference yield:

methyl 4-chloro-6-(2-methoxyphenyl)pyridin-2-carboxylate (925921-89-7) → 6-(2-Methoxy-phenyl)-pyridine-2-carboxylic acid (86696-69-7)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂, 10percent HCl / 10percent Pd/C / methanol / 22 h / 760 Torr

2: 5percent methanolic KOH / 1 h / Ambient temperature

With hydrogenchloride; potassium hydroxide; hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jm00364a026

Reference yield:

6-(2-Methoxy-phenyl)-pyridine-2-carboxylic acid methyl ester → 6-(2-Methoxy-phenyl)-pyridine-2-carboxylic acid (86696-69-7)

Guidance literature:

With potassium hydroxide; for 1h; Ambient temperature;

DOI:10.1021/jm00364a026

upstream raw materials:

methyl 4-chloro-6-(2-methoxyphenyl)pyridin-2-carboxylate

6-bromo-pyridine-2-carboxylic acid

2-Methoxyphenylboronic acid

Downstream raw materials:

6-(2-Methoxy-phenyl)-pyridine-2-carboxylic acid (1H-tetrazol-5-yl)-amide

Refernces

• 1、 Honma,Oda,Hashiyama,Hanamoto,Nakai,Inoue,Ishida,Takeda,Ono,Tsuzurahara. "Antiallergic agents. 2. N-(1H-tetrazol-5-yl)-6-phenyl-2-pyridinecarboxamides". . p. 1499 - 1504. Retrieved 2007/10/02.