(2RS,3SR,6SR)-1-(tert-Butoxycarbonyl)-2-<3-(phenylsulfonyl)propyl>-3-<(1'RS)-1'-(p-tolylsulfonyloxy)ethyl>-6-propylpiperidine

Base Information

Chemical Name:(2RS,3SR,6SR)-1-(tert-Butoxycarbonyl)-2-<3-(phenylsulfonyl)propyl>-3-<(1'RS)-1'-(p-tolylsulfonyloxy)ethyl>-6-propylpiperidine
CAS No.:120475-52-7
Molecular Formula:C₃₁H₄₅NO₇S₂
Molecular Weight:607.833
Hs Code.:

Synonyms:(2RS,3SR,6SR)-1-(tert-Butoxycarbonyl)-2-<3-(phenylsulfonyl)propyl>-3-<(1'RS)-1'-(p-tolylsulfonyloxy)ethyl>-6-propylpiperidine

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Chemical Property of (2RS,3SR,6SR)-1-(tert-Butoxycarbonyl)-2-<3-(phenylsulfonyl)propyl>-3-<(1'RS)-1'-(p-tolylsulfonyloxy)ethyl>-6-propylpiperidine

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Technology Process of (2RS,3SR,6SR)-1-(tert-Butoxycarbonyl)-2-<3-(phenylsulfonyl)propyl>-3-<(1'RS)-1'-(p-tolylsulfonyloxy)ethyl>-6-propylpiperidine

There total 11 articles about (2RS,3SR,6SR)-1-(tert-Butoxycarbonyl)-2-<3-(phenylsulfonyl)propyl>-3-<(1'RS)-1'-(p-tolylsulfonyloxy)ethyl>-6-propylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 120447-76-9
(2RS,3SR,6SR)-1-(tert-Butoxycarbonyl)-2-<3-(phenylsulfonyl)propyl>-3-<(1'RS)-1'-hydroxyethyl>-6-propylpiperidine

: 98-59-9
p-toluenesulfonyl chloride

: 120475-52-7
(2RS,3SR,6SR)-1-(tert-Butoxycarbonyl)-2-<3-(phenylsulfonyl)propyl>-3-<(1'RS)-1'-(p-tolylsulfonyloxy)ethyl>-6-propylpiperidine

Guidance literature:: With pyridine; at 0 ℃; for 16h;
DOI:10.1021/ja00191a038

Reference yield:

: 3112-85-4
methylphenylsulfonate

: 120475-52-7
(2RS,3SR,6SR)-1-(tert-Butoxycarbonyl)-2-<3-(phenylsulfonyl)propyl>-3-<(1'RS)-1'-(p-tolylsulfonyloxy)ethyl>-6-propylpiperidine

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) n-butyllithium / 1.) THF, hexane, 0 deg C, 20 min; 2.) -78 deg C -> room temp., 3 h

2: 80 percent / HCl / acetone; H₂O / 3 h / Ambient temperature

3: Na₂SO₄ / benzene / 0 - 10 °C

4: benzene / 10 h / Heating

5: 87 percent / zinc dust / aq. acetic acid

6: 82 percent / NaOH / tetrahydrofuran; H₂O

7: 92 percent / pyridine / 16 h / 0 °C

With pyridine; hydrogenchloride; sodium hydroxide; n-butyllithium; sodium sulfate; zinc; In tetrahydrofuran; water; acetic acid; acetone; benzene;
DOI:10.1021/ja00191a038

Reference yield:

: 120447-86-1
(Z)-7-Nonen-4-one oxime

: 120475-52-7
(2RS,3SR,6SR)-1-(tert-Butoxycarbonyl)-2-<3-(phenylsulfonyl)propyl>-3-<(1'RS)-1'-(p-tolylsulfonyloxy)ethyl>-6-propylpiperidine

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / sodium cyanoborohydride, 50percent methanolic HCl / methanol

2: Na₂SO₄ / benzene / 0 - 10 °C

3: benzene / 10 h / Heating

4: 87 percent / zinc dust / aq. acetic acid

5: 82 percent / NaOH / tetrahydrofuran; H₂O

6: 92 percent / pyridine / 16 h / 0 °C

With pyridine; hydrogenchloride; sodium hydroxide; sodium cyanoborohydride; sodium sulfate; zinc; In tetrahydrofuran; methanol; water; acetic acid; benzene;
DOI:10.1021/ja00191a038