5-(8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

Base Information

Chemical Name:5-(8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol
CAS No.:38849-59-1
Molecular Formula:C₂₀H₂₄BrNO₄
Molecular Weight:422.319
Hs Code.:

Synonyms:5-(8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

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Chemical Property of 5-(8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

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Technology Process of 5-(8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

There total 11 articles about 5-(8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.6%

: 23495-76-3,32725-64-7
1-(3-benzyloxy-4-methoxy-benzyl)-8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinoline

: 38849-59-1
5-(8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

Guidance literature:: With trifluoroacetic acid; In methanol; for 6h; Reagent/catalyst; Solvent; Reflux; Inert atmosphere;

Reference yield:

: 1131-94-8
homoisovanillic acid

: 38849-59-1
5-(8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium iodide; sodium hydroxide / isopropyl alcohol / 6 h / 20 - 70 °C

2.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C

2.2: 2 h

3.1: trichlorophosphate / toluene / 6 h / Inert atmosphere; Reflux

4.1: potassium borohydride / ethanol / 3 h / 40 °C

5.1: sodium hydroxide / dichloromethane / 1 h / 20 °C

5.2: 5 h / Reflux

6.1: trifluoroacetic acid / methanol / 6 h / Reflux; Inert atmosphere

With potassium borohydride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; potassium iodide; sodium hydroxide; trichlorophosphate; In methanol; ethanol; dichloromethane; isopropyl alcohol; toluene;

Reference yield:

: 5487-33-2
O-benzylhomoisovanillic acid

: 38849-59-1
5-(8-bromo-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-1-ylmethyl)-2-methoxy-phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1,1'-carbonyldiimidazole / dichloromethane / 2 h / 20 °C

1.2: 2 h

2.1: trichlorophosphate / toluene / 6 h / Inert atmosphere; Reflux

3.1: potassium borohydride / ethanol / 3 h / 40 °C

4.1: sodium hydroxide / dichloromethane / 1 h / 20 °C

4.2: 5 h / Reflux

5.1: trifluoroacetic acid / methanol / 6 h / Reflux; Inert atmosphere

With potassium borohydride; 1,1'-carbonyldiimidazole; trifluoroacetic acid; sodium hydroxide; trichlorophosphate; In methanol; ethanol; dichloromethane; toluene;