(S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

Base Information

Chemical Name:(S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester
CAS No.:138505-84-7
Molecular Formula:C₃₉H₆₀O₄Si₂
Molecular Weight:649.074
Hs Code.:

(S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

Synonyms:(S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

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Chemical Property of (S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

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Technology Process of (S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

There total 11 articles about (S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138505-81-4
ethyl (1S,2S,4aR,6R,8S,8aS)-1,2,4a,5,6,7,8,8a-octahydro-6,8-dihydroxy-2-methylnaphthalene-1-carboxylate

: 138505-84-7
(S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 16 h

2: LiAlH₄ / diethyl ether / 1 h

3: 86 percent / CH₂Cl₂ / 18 h

4: 0.734 g / DMAP, pyridine / CH₂Cl₂ / 26 h

With pyridine; 1H-imidazole; dmap; lithium aluminium tetrahydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00096a015

Reference yield:

: 138505-80-3
ethyl (1S,2S,4aR,6R,8S,8aS)-6-acetoxy-1,2,4a,5,6,7,8,8a-octahydro-8-hydroxy-2-methylnaphthalene-1-carboxylate

: 138505-84-7
(S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / sodium ethoxide / ethanol / 0.5 h

2: imidazole / dimethylformamide / 16 h

3: LiAlH₄ / diethyl ether / 1 h

4: 86 percent / CH₂Cl₂ / 18 h

5: 0.734 g / DMAP, pyridine / CH₂Cl₂ / 26 h

With pyridine; 1H-imidazole; dmap; lithium aluminium tetrahydride; sodium ethanolate; In diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00096a015

Reference yield:

: 142437-81-8
(1R,2R,4aS,6R,8S,8aR)-6-Acetyl-3,4-dibromo-8-hydroxy-2-methyl-decahydro-naphthalene-1-carboxylic acid ethyl ester

: 138505-84-7
(S)-2-Methyl-butyric acid (1S,3R,4aR,7S,8S,8aS)-8-(tert-butyl-dimethyl-silanyloxymethyl)-3-(tert-butyl-diphenyl-silanyloxy)-7-methyl-1,2,3,4,4a,7,8,8a-octahydro-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: trifluoroacetic anhydride, H₂O₂ / H₂O; CH₂Cl₂ / 0.5 h

2: Zn, acetic acid / diethyl ether / 0.25 h

3: 90 percent / sodium ethoxide / ethanol / 0.5 h

4: imidazole / dimethylformamide / 16 h

5: LiAlH₄ / diethyl ether / 1 h

6: 86 percent / CH₂Cl₂ / 18 h

7: 0.734 g / DMAP, pyridine / CH₂Cl₂ / 26 h

With pyridine; 1H-imidazole; dmap; lithium aluminium tetrahydride; dihydrogen peroxide; sodium ethanolate; acetic acid; trifluoroacetic anhydride; zinc; In diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00096a015