Chemical Property of 6-Methyl-2-(p-tolylamino)-4H-benzo[d][1,3]oxazin-4-one
Chemical Property:
- Appearance/Colour:off-white solid
- Vapor Pressure:9.8E-08mmHg at 25°C
- Melting Point:238-240 °C
- Refractive Index:1.627
- Boiling Point:434 °C at 760 mmHg
- PKA:3.76±0.20(Predicted)
- Flash Point:216.3 °C
- PSA：55.13000
- Density:1.23 g/cm3
- LogP:3.62140
- Storage Temp.:Refrigerator
- Solubility.:DMSO (Slightly), Methanol (Slightly, Heated)
- XLogP3:3.4
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:3
- Rotatable Bond Count:2
- Exact Mass:266.105527694
- Heavy Atom Count:20
- Complexity:399
- Purity/Quality:
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99%, *data from raw suppliers
URB754 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
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SDS file from LookChem
Useful:
- Canonical SMILES:CC1=CC=C(C=C1)NC2=NC3=C(C=C(C=C3)C)C(=O)O2
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Description
URB754 is a potent and noncompetitive inhibitor of monoacylglycerol lipase (MAGL), exhibiting an IC50 value of 200 nM for the recombinant rat brain enzyme. However, it does not inhibit human recombinant, rat brain, or mouse brain MAGL at concentrations up to 100 μM. There is evidence that the MAGL inhibitory activity of URB754 may be attributed to the impurity bis(methylthio)mercurane (IC50 = 11.9 nM for rat recombinant MAGL) that is found in commercial preparations. URB754 inhibits rat brain fatty acyl amide hydrolase (FAAH) with an IC50 value of 32 μM and binds weakly to the rat central cannabinoid (CB1) receptor with an IC50 value of 3.8 μM. It does not inhibit COX-1 or COX-2 at concentrations up to 100 μM. Inhibition of MAGL hydrolysis of 2-arachidonoyl glycerol (2-AG) is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
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Uses
URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 and binds weakly to the rat CB1 r URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 μM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 μM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 μM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.
