BETA-OXO-4-DIMETHYLAMINO-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

Base Information

• Chemical Name: BETA-OXO-4-DIMETHYLAMINO-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER
• CAS No.: 138714-61-1
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.337
• Mol file: 138714-61-1.mol

Synonyms:3-(4-Dimethylamino-phenyl)-3-oxo-propionic acid tert-butyl ester

Chemical Property of BETA-OXO-4-DIMETHYLAMINO-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

tert-Butylb-oxo-4-dimethylaminobenzenepropanoate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of BETA-OXO-4-DIMETHYLAMINO-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER

There total 3 articles about BETA-OXO-4-DIMETHYLAMINO-BENZENEPROPANOIC ACID 1,1-DIMETHYLETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid tert-butyl ester (540-88-5) + ethyl p-dimethyaminolbenzoate (10287-53-3) → 3-(4-Dimethylamino-phenyl)-3-oxo-propionic acid tert-butyl ester (138714-61-1)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -78 deg C, 0.5 h, 2.) THF, 25 deg C, 16 h;

Reference yield:

4-(dimethylamino)benzoyl chloride (4755-50-4) → 3-(4-Dimethylamino-phenyl)-3-oxo-propionic acid tert-butyl ester (138714-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / Ambient temperature

2: 1.) LDA / 1.) THF, -78 deg C, 0.5 h, 2.) THF, 25 deg C, 16 h

With lithium diisopropyl amide; In benzene;

Reference yield:

p-N,N-dimethylaminobenzoic acid (619-84-1) → 3-(4-Dimethylamino-phenyl)-3-oxo-propionic acid tert-butyl ester (138714-61-1)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl chloride, DMF / benzene / 2 h / 10 °C

2: benzene / Ambient temperature

3: 1.) LDA / 1.) THF, -78 deg C, 0.5 h, 2.) THF, 25 deg C, 16 h

With oxalyl dichloride; N,N-dimethyl-formamide; lithium diisopropyl amide; In benzene;

upstream raw materials:

acetic acid tert-butyl ester

ethyl p-dimethyaminolbenzoate

4-(dimethylamino)benzoyl chloride

p-N,N-dimethylaminobenzoic acid

Downstream raw materials:

1-Benzyl-2-(4-dimethylamino-phenyl)-4-isopropyl-3-oxo-2,3-dihydro-1H-pyrrole-2-carboxylic acid tert-butyl ester

t-butyl 2,3-dioxo-3-(4-dimethylaminophenyl)propionate