2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-α-D-glucopyranosyl trichloroacetimidate

Base Information

Chemical Name:2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-α-D-glucopyranosyl trichloroacetimidate
CAS No.:1374562-19-2
Molecular Formula:C₄₂H₄₂BrCl₃N₄O₅Si
Molecular Weight:897.168
Hs Code.:

Synonyms:2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-α-D-glucopyranosyl trichloroacetimidate

Suppliers and Price of 2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-α-D-glucopyranosyl trichloroacetimidate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-α-D-glucopyranosyl trichloroacetimidate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-α-D-glucopyranosyl trichloroacetimidate

There total 6 articles about 2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-α-D-glucopyranosyl trichloroacetimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₄₀H₄₂BrN₃O₅Si

: 545-06-2
trichloroacetonitrile

: 1374562-19-2
2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-α-D-glucopyranosyl trichloroacetimidate

: 1374562-20-5
2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-β-D-glucopyranosyl trichloroacetimidate

Guidance literature:: With potassium carbonate; In dichloromethane; at 0 - 20 ℃; for 24h; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ja302640p

Reference yield:

: 1374562-16-9
C₃₁H₂₆BrN₃O₆

: 1374562-19-2
2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-α-D-glucopyranosyl trichloroacetimidate

: 1374562-20-5
2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-β-D-glucopyranosyl trichloroacetimidate

Guidance literature:: Multi-step reaction with 4 steps

1: borane-THF; copper(II) bis(trifluoromethanesulfonate) / tetrahydrofuran / 6 h / 0 - 20 °C / Inert atmosphere

2: dmap; triethylamine / dichloromethane / 24 h / Inert atmosphere; Cooling with ice

3: methanol; ammonia / tetrahydrofuran / 24 h / 0 °C

4: potassium carbonate / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With methanol; dmap; borane-THF; ammonia; copper(II) bis(trifluoromethanesulfonate); potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja302640p

Reference yield:

: 1374562-17-0
C₃₁H₂₈BrN₃O₆

: 1374562-19-2
2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-α-D-glucopyranosyl trichloroacetimidate

: 1374562-20-5
2-azido-3-O-(4-bromobenzyl)-6-O-tert-butyldiphenylsilyl-2-deoxy-4-O-(2-naphthylmethyl)-β-D-glucopyranosyl trichloroacetimidate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 24 h / Inert atmosphere; Cooling with ice

2: methanol; ammonia / tetrahydrofuran / 24 h / 0 °C

3: potassium carbonate / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

With methanol; dmap; ammonia; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja302640p