1-cyclohexylidene-3-fluoro-2-oxaspiro[4.5]dec-3-ene

Base Information

• Chemical Name: 1-cyclohexylidene-3-fluoro-2-oxaspiro[4.5]dec-3-ene
• CAS No.: 1426575-49-6
• Molecular Formula: C₁₅H₂₁FO
• Molecular Weight: 236.33
• Mol file: 1426575-49-6.mol

Synonyms:1-cyclohexylidene-3-fluoro-2-oxaspiro[4.5]dec-3-ene

Chemical Property of 1-cyclohexylidene-3-fluoro-2-oxaspiro[4.5]dec-3-ene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-cyclohexylidene-3-fluoro-2-oxaspiro[4.5]dec-3-ene

There total 5 articles about 1-cyclohexylidene-3-fluoro-2-oxaspiro[4.5]dec-3-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

cyclohexyl[1-(2,2-difluorovinyl)cyclohexyl]methanone (1426575-58-7) → 1-cyclohexylidene-3-fluoro-2-oxaspiro[4.5]dec-3-ene (1426575-49-6)

Guidance literature:

With potassium hydride; In tetrahydrofuran; mineral oil; for 2h; pH=7; Inert atmosphere; Reflux;

DOI:10.1055/s-0032-1317709

Reference yield:

N-(cyclohexylmethylene)-2-methylpropan-2-amine (53188-66-2) → 1-cyclohexylidene-3-fluoro-2-oxaspiro[4.5]dec-3-ene (1426575-49-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere; Reflux

1.3: 1 h / 0 °C

2.1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere; Molecular sieve

2.2: 10 h / 20 °C / pH 7 / Inert atmosphere

3.1: potassium hydride / tetrahydrofuran; mineral oil / 2 h / pH 7 / Inert atmosphere; Reflux

With tert.-butyl lithium; potassium hydride; Hexamethylphosphorous triamide; In tetrahydrofuran; mineral oil; pentane;

DOI:10.1055/s-0032-1317709

Reference yield:

cyclohexanylcarbonyl chloride (2719-27-9) → 1-cyclohexylidene-3-fluoro-2-oxaspiro[4.5]dec-3-ene (1426575-49-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0 °C / Inert atmosphere

1.2: 2 h / Inert atmosphere; Reflux

1.3: 1 h / 0 °C

2.1: Hexamethylphosphorous triamide / tetrahydrofuran / 0.25 h / -78 °C / Inert atmosphere; Molecular sieve

2.2: 10 h / 20 °C / pH 7 / Inert atmosphere

3.1: potassium hydride / tetrahydrofuran; mineral oil / 2 h / pH 7 / Inert atmosphere; Reflux

With tert.-butyl lithium; potassium hydride; Hexamethylphosphorous triamide; In tetrahydrofuran; mineral oil; pentane;

DOI:10.1055/s-0032-1317709

upstream raw materials:

cyclohexyl[1-(2,2-difluorovinyl)cyclohexyl]methanone

N-(cyclohexylmethylene)-2-methylpropan-2-amine

cyclohexanylcarbonyl chloride

1-(cyclohexanecarbonyl)cyclohexanecarbaldehyde