3-[2-(4-Chloro-benzylamino)-5-iodo-benzoylamino]-propionic acid ethyl ester

Base Information

• Chemical Name: 3-[2-(4-Chloro-benzylamino)-5-iodo-benzoylamino]-propionic acid ethyl ester
• CAS No.: 151978-68-6
• Molecular Formula: C₁₉H₂₀ClIN₂O₃
• Molecular Weight: 486.737
• Mol file: 151978-68-6.mol

Synonyms:3-[2-(4-Chloro-benzylamino)-5-iodo-benzoylamino]-propionic acid ethyl ester

Chemical Property of 3-[2-(4-Chloro-benzylamino)-5-iodo-benzoylamino]-propionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3-[2-(4-Chloro-benzylamino)-5-iodo-benzoylamino]-propionic acid ethyl ester

There total 8 articles about 3-[2-(4-Chloro-benzylamino)-5-iodo-benzoylamino]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Chloro-4-(chloromethyl)benzene (104-83-6) + 3-(2-amino-5-iodo)benzamidopropionic acid ethyl ester (151978-67-5) → 3-[2-(4-Chloro-benzylamino)-5-iodo-benzoylamino]-propionic acid ethyl ester (151978-68-6)

Guidance literature:

With 2,6-dimethylpyridine; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1021/ja00091a008

Reference yield:

5-iodoisatoic anhydride (116027-10-2) → 3-[2-(4-Chloro-benzylamino)-5-iodo-benzoylamino]-propionic acid ethyl ester (151978-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N, DMAP / dimethylformamide

2: 2,6-lutidine / dimethylformamide / 100 °C

With 2,6-dimethylpyridine; dmap; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/ja00091a008

Reference yield:

ethyl β-alaninate hydrochloride (4244-84-2) → 3-[2-(4-Chloro-benzylamino)-5-iodo-benzoylamino]-propionic acid ethyl ester (151978-68-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N, DMAP / dimethylformamide

2: 2,6-lutidine / dimethylformamide / 100 °C

With 2,6-dimethylpyridine; dmap; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/ja00091a008

upstream raw materials:

1-Chloro-4-(chloromethyl)benzene

3-(2-amino-5-iodo)benzamidopropionic acid ethyl ester

ethyl β-alaninate hydrochloride

5-iodoisatoic anhydride