4-(allyloxy)-3,3-dichloro-1-isopropyl-4-(4-nitrophenyl)azetidin-2-one

Base Information

• Chemical Name: 4-(allyloxy)-3,3-dichloro-1-isopropyl-4-(4-nitrophenyl)azetidin-2-one
• CAS No.: 1252581-02-4
• Molecular Formula: C₁₅H₁₆Cl₂N₂O₄
• Molecular Weight: 359.209
• Mol file: 1252581-02-4.mol

Synonyms:4-(allyloxy)-3,3-dichloro-1-isopropyl-4-(4-nitrophenyl)azetidin-2-one

Chemical Property of 4-(allyloxy)-3,3-dichloro-1-isopropyl-4-(4-nitrophenyl)azetidin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of 4-(allyloxy)-3,3-dichloro-1-isopropyl-4-(4-nitrophenyl)azetidin-2-one

There total 1 articles about 4-(allyloxy)-3,3-dichloro-1-isopropyl-4-(4-nitrophenyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

dichloroacethyl chloride (79-36-7) + allyl N-isopropyl-4-nitrobenzimidate (1252580-93-0) → 4-(allyloxy)-3,3-dichloro-1-isopropyl-4-(4-nitrophenyl)azetidin-2-one (1252581-02-4)

Guidance literature:

With triethylamine; In benzene; at 25 - 30 ℃; for 2.25h;

DOI:10.1021/jo101045z

Reference yield: 79.0%

4-(allyloxy)-3,3-dichloro-1-isopropyl-4-(4-nitrophenyl)azetidin-2-one (1252581-02-4) → 3-chloro-4-chloromethyl-1-isopropyl-6-(4-nitrophenyl)tetrahydrofuro[3,2-c]azetidin-2-one

Guidance literature:

With N,N,N',N'',N'''-pentamethyldiethylenetriamine; copper(l) chloride; In 1,2-dichloro-ethane; for 4h; diastereoselective reaction; Inert atmosphere; Reflux;

DOI:10.1021/jo101045z

upstream raw materials:

dichloroacethyl chloride

allyl N-isopropyl-4-nitrobenzimidate