methyl N-benzyloxycarbonyl-(1R,3S,5R)-2-azabicyclo<3.3.0>octane-3-carboxylate

Base Information

Chemical Name:methyl N-benzyloxycarbonyl-(1R,3S,5R)-2-azabicyclo<3.3.0>octane-3-carboxylate
CAS No.:121154-35-6
Molecular Formula:C₁₇H₂₁NO₄
Molecular Weight:303.358
Hs Code.:

Synonyms:methyl N-benzyloxycarbonyl-(1R,3S,5R)-2-azabicyclo<3.3.0>octane-3-carboxylate

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Chemical Property of methyl N-benzyloxycarbonyl-(1R,3S,5R)-2-azabicyclo<3.3.0>octane-3-carboxylate

Chemical Property:

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Technology Process of methyl N-benzyloxycarbonyl-(1R,3S,5R)-2-azabicyclo<3.3.0>octane-3-carboxylate

There total 6 articles about methyl N-benzyloxycarbonyl-(1R,3S,5R)-2-azabicyclo<3.3.0>octane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: aqueous KF

: Methyl 2-(S)-[N-benzyloxycarbonyl-N-(2-(1R,S)-cyclopenten-1-ylamino)]-3-iodopropionate

: 688-73-3
tri-n-butyl-tin hydride

: 121154-35-6
methyl N-benzyloxycarbonyl-(1R,3S,5R)-2-azabicyclo<3.3.0>octane-3-carboxylate

Guidance literature:: With 2,2'-azobis(isobutyronitrile); In cyclohexane; ethyl acetate; benzene;

Reference yield:

: 36291-48-2
3-bromocyclopentene

: 121154-35-6
methyl N-benzyloxycarbonyl-(1R,3S,5R)-2-azabicyclo<3.3.0>octane-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 36 percent / K₂CO₃ / acetonitrile / 2 h / Ambient temperature

2: 90 percent / NaHCO₃ / H₂O / 1.33 h

3: 45.3 percent / triphenylphosphine, imidazole, iodine / benzene / 5 h / Ambient temperature

4: 2,2'-azoisobutyronitrile, tri-n-butyltin hydride / benzene / 4 h / Heating

With 1H-imidazole; 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; sodium hydrogencarbonate; potassium carbonate; triphenylphosphine; In water; acetonitrile; benzene;
DOI:10.3987/COM-88-S111

Reference yield:

: 121080-45-3
N-(2-(1R,S)-cyclopenten-1-yl)-L-serine methyl ester

: 121154-35-6
methyl N-benzyloxycarbonyl-(1R,3S,5R)-2-azabicyclo<3.3.0>octane-3-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 90 percent / NaHCO₃ / H₂O / 1.33 h

2: 45.3 percent / triphenylphosphine, imidazole, iodine / benzene / 5 h / Ambient temperature

3: 2,2'-azoisobutyronitrile, tri-n-butyltin hydride / benzene / 4 h / Heating

With 1H-imidazole; 2,2'-azobis(isobutyronitrile); iodine; tri-n-butyl-tin hydride; sodium hydrogencarbonate; triphenylphosphine; In water; benzene;
DOI:10.3987/COM-88-S111