((2R,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butyl)-phosphonic acid dimethyl ester; hydrochloride

Base Information

Chemical Name:((2R,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butyl)-phosphonic acid dimethyl ester; hydrochloride
CAS No.:123381-48-6
Molecular Formula:C₁₂H₂₆NO₄P*ClH
Molecular Weight:315.777
Hs Code.:

Synonyms:((2R,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butyl)-phosphonic acid dimethyl ester; hydrochloride

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Chemical Property of ((2R,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butyl)-phosphonic acid dimethyl ester; hydrochloride

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Technology Process of ((2R,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butyl)-phosphonic acid dimethyl ester; hydrochloride

There total 6 articles about ((2R,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butyl)-phosphonic acid dimethyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123381-15-7
(2R,3S)-dimethyl <3-(t-Boc-amino)-4-cyclohexyl-2-hydroxybutyl>phosphonate

: 123381-48-6
((2R,3S)-3-Amino-4-cyclohexyl-2-hydroxy-butyl)-phosphonic acid dimethyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 2h; Ambient temperature;
DOI:10.1021/jm00164a011

Reference yield:

: 123381-23-7,123381-24-8
[(S)-4-Cyclohexyl-2-hydroxy-3-(trityl-amino)-butyl]-phosphonic acid dimethyl ester

: 123381-48-6,123381-49-7
((S)-3-Amino-4-cyclohexyl-2-hydroxy-butyl)-phosphonic acid dimethyl ester; hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; for 0.5h; Ambient temperature;
DOI:10.1021/jm00164a011

Reference yield:

: 123381-14-6
N-tritylcyclohexylalaninol

: 123381-48-6,123381-49-7
((S)-3-Amino-4-cyclohexyl-2-hydroxy-butyl)-phosphonic acid dimethyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride, dimethylsulfoxide, triethylamine / CH₂Cl₂ / 0.5 h / -60 °C

2: 1.) n-butyllithium / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) 0.5 h

3: 4.5 M HCl / dioxane / 0.5 h / Ambient temperature

With hydrogenchloride; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00164a011