(8R,11R,14S)-8-Amino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

Base Information

• Chemical Name: (8R,11R,14S)-8-Amino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester
• CAS No.: 586413-68-5
• Molecular Formula: C₂₉H₂₉Cl₂N₃O₇
• Molecular Weight: 602.471

Synonyms:(8R,11R,14S)-8-Amino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

Chemical Property of (8R,11R,14S)-8-Amino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (8R,11R,14S)-8-Amino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

There total 10 articles about (8R,11R,14S)-8-Amino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(8R,11R,14S)-8-tert-Butoxycarbonylamino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]henicosa-1(19),3(21),4,6,16(20),17-hexaene-14-carboxylic acid methyl ester (586413-52-7) → (8R,11R,14S)-8-Amino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]henicosa-1(19),3(21),4,6,16(20),17-hexaene-14-carboxylic acid methyl ester (586413-68-5)

Guidance literature:

With hydrogenchloride; In methanol; at 22 ℃; for 1.5h;

DOI:10.1021/ja030249r

Reference yield:

isovanillin (621-59-0) → (8R,11R,14S)-8-Amino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]henicosa-1(19),3(21),4,6,16(20),17-hexaene-14-carboxylic acid methyl ester (586413-68-5)

Guidance literature:

Multi-step reaction with 8 steps

1: 98 percent / imidazole / dimethylformamide / 0.5 h

2: 98 percent / MgSO₄ / benzene / 24 h

3: Ti(O-i-Pr)4; chiral amino acid ligand; isopropanol / toluene / 4 h

4: 3.11 g / NaHCO₃; 1-hydroxy-7-azabenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / tetrahydrofuran; dimethylformamide / 12 h / 22 °C

5: NH₄OAc; aq. NaIO₄ / acetone / 12 h / 22 °C

6: 650 mg / Cu(OAc)2; 4A molecular sieves; Et₃N / CH₂Cl₂; methanol / 6 h / 22 °C

7: 98 percent / HCl / methanol / 1.5 h / 22 °C

With 1H-imidazole; titanium(IV) isopropylate; hydrogenchloride; sodium periodate; 1-hydroxy-7-aza-benzotriazole; copper diacetate; 4 A molecular sieve; chiral amino acid ligand; ammonium acetate; sodium hydrogencarbonate; magnesium sulfate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; isopropyl alcohol; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; benzene;

DOI:10.1021/ja030249r

Reference yield:

p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde (97315-18-9) → (8R,11R,14S)-8-Amino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.13,7]henicosa-1(19),3(21),4,6,16(20),17-hexaene-14-carboxylic acid methyl ester (586413-68-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 98 percent / MgSO₄ / benzene / 24 h

2: Ti(O-i-Pr)4; chiral amino acid ligand; isopropanol / toluene / 4 h

3: 3.11 g / NaHCO₃; 1-hydroxy-7-azabenzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide / tetrahydrofuran; dimethylformamide / 12 h / 22 °C

4: NH₄OAc; aq. NaIO₄ / acetone / 12 h / 22 °C

5: 650 mg / Cu(OAc)2; 4A molecular sieves; Et₃N / CH₂Cl₂; methanol / 6 h / 22 °C

6: 98 percent / HCl / methanol / 1.5 h / 22 °C

With titanium(IV) isopropylate; hydrogenchloride; sodium periodate; 1-hydroxy-7-aza-benzotriazole; copper diacetate; 4 A molecular sieve; chiral amino acid ligand; ammonium acetate; sodium hydrogencarbonate; magnesium sulfate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; isopropyl alcohol; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; acetone; toluene; benzene;

DOI:10.1021/ja030249r

upstream raw materials:

(8R,11R,14S)-8-tert-Butoxycarbonylamino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

isovanillin

p-methoxy-m-(tert-butyldimethylsilyloxy)-benzaldehyde

(R)-N-Boc-m-hydroxy-p-methoxyphenyl-Gly

Downstream raw materials:

(8R,11R,14S)-11-(3,5-Dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-8-(2,2,2-trifluoro-acetylamino)-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

(8R,11R,14S)-11-(3,5-Dichloro-4-hydroxy-phenyl)-4-hydroxy-13-methyl-9,12-dioxo-8-(2,2,2-trifluoro-acetylamino)-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid

(R)-{[(8R,11R,14S)-8-Amino-11-(3,5-dichloro-4-hydroxy-phenyl)-4-hydroxy-5-iodo-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carbonyl]-amino}-(4-hydroxy-phenyl)-acetic acid methyl ester

C₄₃H₄₅Cl₂F₃N₄O₁₀Si

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 586413-68-5 (8R,11R,14S)-8-Amino-11-(3,5-dichloro-4-methoxy-phenyl)-4-methoxy-13-methyl-9,12-dioxo-2-oxa-10,13-diaza-tricyclo[14.2.2.1^3,7]henicosa-1⁽¹⁹⁾,3⁽²¹⁾,4,6,16⁽²⁰⁾,17-hexaene-14-carboxylic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send