[3-(3-hydroxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile

Base Information

Chemical Name:[3-(3-hydroxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile
CAS No.:1192885-91-8
Molecular Formula:C₂₂H₁₇N₅O
Molecular Weight:367.41
Hs Code.:

Synonyms:[3-(3-hydroxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile

Suppliers and Price of [3-(3-hydroxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [3-(3-hydroxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [3-(3-hydroxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile

There total 7 articles about [3-(3-hydroxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1192885-53-2
[3-(3-methoxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile

: 1192885-91-8
[3-(3-hydroxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile

Guidance literature:: With boron dimethyl-trifluoro sulphide; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

Reference yield:

: 585-81-9
3-hydroxy-5-methylbenzoic acid

: 1192885-91-8
[3-(3-hydroxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dmap / acetone / 12 h / 65 °C

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

3.1: 12 h / Reflux

3.2: 2 h / 20 °C

4.1: potassium carbonate / acetone / 2 h / Reflux

4.2: 2 h / Reflux

4.3: 12 h / 70 °C / Inert atmosphere

5.1: boron dimethyl-trifluoro sulphide / dichloromethane / 24 h / 20 °C / Inert atmosphere

With boron dimethyl-trifluoro sulphide; potassium carbonate; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; dichloromethane; acetone;

Reference yield:

: 624-75-9
iodoacetonitrile

: 1192885-45-2
2-chloro-4-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridine

: 1692-25-7
3-pyridylboronic acid

: 1192886-07-9
[5-(3-hydroxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile

: 1192885-91-8
[3-(3-hydroxy-5-methylphenyl)-4-(2-(pyridin-3-yl)pyridin-4-yl)-pyrazol-1-yl]acetonitrile

Guidance literature:: iodoacetonitrile; 2-chloro-4-(3-(3-methoxy-5-methylphenyl)-1H-pyrazol-4-yl)pyridine; With potassium carbonate; In acetone; for 4h; Reflux;

3-pyridylboronic acid; With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In tetrahydrofuran; water; at 70 ℃; for 12h; Inert atmosphere;

With boron dimethyl-trifluoro sulphide; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmcl.2009.08.029