tert-butyl 4-(4-amino-3-methyl-5-nitrophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

Base Information

Chemical Name:tert-butyl 4-(4-amino-3-methyl-5-nitrophenyl)-3,6-dihydropyridine-1(2H)-carboxylate
CAS No.:1054315-49-9
Molecular Formula:C₁₇H₂₃N₃O₄
Molecular Weight:333.387
Hs Code.:

Synonyms:tert-butyl 4-(4-amino-3-methyl-5-nitrophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

Suppliers and Price of tert-butyl 4-(4-amino-3-methyl-5-nitrophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
tert-Butyl4-(4-amino-3-methyl-5-nitrophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 97%
5g
$ 2700.00

Matrix Scientific
tert-Butyl4-(4-amino-3-methyl-5-nitrophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 97%
1g
$ 1080.00

Total 2 raw suppliers

Chemical Property of tert-butyl 4-(4-amino-3-methyl-5-nitrophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

tert-Butyl4-(4-amino-3-methyl-5-nitrophenyl)-5,6-dihydropyridine-1(2H)-carboxylate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Useful:

Technology Process of tert-butyl 4-(4-amino-3-methyl-5-nitrophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

There total 4 articles about tert-butyl 4-(4-amino-3-methyl-5-nitrophenyl)-3,6-dihydropyridine-1(2H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 77811-44-0
4-bromo-2-methyl-6-nitroaniline

: 375853-82-0,286961-14-6
tert-Butyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate

: 1054315-49-9
tert-butyl 4-(4-amino-3-methyl-5-nitrophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 80 ℃; for 17h; Inert atmosphere;

Reference yield: 58.0%

: 956821-91-3
2-methyl-6-nitro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

: 138647-49-1
4-Trifluoromethanesulfonyloxy-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester

: 1054315-49-9
tert-butyl 4-(4-amino-3-methyl-5-nitrophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; lithium chloride; In 1,2-dimethoxyethane; water; at 80 ℃; for 14h; Inert atmosphere;
DOI:10.1021/jm800832q

Reference yield:

: N-(4-bromo-2-methyl-6-nitrophenyl)-2,2,2-trifluoroacetamide

: 1054315-49-9
tert-butyl 4-(4-amino-3-methyl-5-nitrophenyl)-3,6-dihydropyridine-1(2H)-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol; water / 1 h / Reflux

2: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 17 h / 80 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; methanol; water;