1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-ε-acetylamide-N-α-carbobenzyloxy-L-lysine benzyl ester

Base Information

Chemical Name:1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-ε-acetylamide-N-α-carbobenzyloxy-L-lysine benzyl ester
CAS No.:686777-04-8
Molecular Formula:C₄₉H₇₆N₆O₁₁
Molecular Weight:925.176
Hs Code.:

Synonyms:1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-ε-acetylamide-N-α-carbobenzyloxy-L-lysine benzyl ester

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Chemical Property of 1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-ε-acetylamide-N-α-carbobenzyloxy-L-lysine benzyl ester

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Technology Process of 1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-ε-acetylamide-N-α-carbobenzyloxy-L-lysine benzyl ester

There total 5 articles about 1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-ε-acetylamide-N-α-carbobenzyloxy-L-lysine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 122555-91-3
1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane

: 686777-03-7
N-ε-bromoacetylamide-N-α-carbobenzyloxy-L-lysine benzyl ester

: 686777-04-8
1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-ε-acetylamide-N-α-carbobenzyloxy-L-lysine benzyl ester

Guidance literature:: 1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane; With potassium carbonate; In acetonitrile; at 60 ℃; for 0.25h;

N-ε-bromoacetylamide-N-α-carbobenzyloxy-L-lysine benzyl ester; In acetonitrile; at 60 ℃; for 72h;
DOI:10.1002/chem.200305389

Reference yield:

: 5591-94-6
N^(α)-benzyloxycarbonyl-L-lysine benzyl ester

: 686777-04-8
1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-ε-acetylamide-N-α-carbobenzyloxy-L-lysine benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97.7 percent / (i-Pr)2NEt / CH₂Cl₂ / -30 - 20 °C

2.1: K₂CO₃ / acetonitrile / 0.25 h / 60 °C

2.2: 100 percent / acetonitrile / 72 h / 60 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; acetonitrile;
DOI:10.1002/chem.200305389

Reference yield:

: 2389-60-8
Z-Lys(Boc)-OH

: 686777-04-8
1,4,7-tris(tert-butylacetate)-1,4,7,10-tetraazacyclododecane-10-N-ε-acetylamide-N-α-carbobenzyloxy-L-lysine benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 98.7 percent / (i-Pr)2NEt / acetonitrile / 48 h / 20 °C

2.1: 94.6 percent / TFA / CH₂Cl₂ / 5 h / 20 °C

3.1: 97.7 percent / (i-Pr)2NEt / CH₂Cl₂ / -30 - 20 °C

4.1: K₂CO₃ / acetonitrile / 0.25 h / 60 °C

4.2: 100 percent / acetonitrile / 72 h / 60 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; acetonitrile;
DOI:10.1002/chem.200305389