(S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethylamine

Base Information

• Chemical Name: (S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethylamine
• CAS No.: 1393176-26-5
• Molecular Formula: C₁₆H₁₇N₃
• Molecular Weight: 251.331
• Mol file: 1393176-26-5.mol

Synonyms:(S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethylamine

Chemical Property of (S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethylamine

There total 5 articles about (S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

[(S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethyl]carbamic acid tert-butyl ester (1393176-27-6) → (S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethylamine (1393176-26-5)

Guidance literature:

[(S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethyl]carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In dichloromethane; for 0.166667h;

Reference yield:

aniline (62-53-3) → (S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethylamine (1393176-26-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: dimethyl sulfoxide / 20 h / 100 °C / Inert atmosphere; Sealed tube

2.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

3.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 20 h / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

4.2: 0.17 h

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; In dichloromethane; dimethyl sulfoxide; ethyl acetate;

Reference yield:

4-methyl-2-nitro-N-phenylaniline (16588-32-2) → (S)-1-(5-methyl-1-phenyl-1H-benzoimidazol-2-yl)ethylamine (1393176-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 5 h / 20 °C

2.1: 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 4-methyl-morpholine / dichloromethane / 20 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.2: 0.17 h

With 4-methyl-morpholine; 1-hydroxy-7-aza-benzotriazole; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; palladium 10% on activated carbon; In dichloromethane; ethyl acetate;

upstream raw materials:

aniline

4-fluoro-3-nitrotoluene

4-methyl-2-nitro-N-phenylaniline

4-methyl-N¹-phenylbenzene-1,2-diamine

Downstream raw materials:

(S)-N-(1-(5-methyl-1-phenyl-1H-benzo[d]imidazol-2-yl)ethyl)-9H-purin-6-amine