1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Base Information

• Chemical Name: 1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid
• CAS No.: 86447-11-2
• Molecular Formula: C11H17 N O4
• Molecular Weight: 227.26
• Hs Code.: 2933399090
• Mol file: 86447-11-2.mol

Synonyms:1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Chemical Property of 1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.519
• Boiling Point: 356.942°C at 760 mmHg
• Flash Point: 169.673°C
• PSA: 66.84000
• Density: 1.207g/cm³
• LogP: 1.57610
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid

There total 18 articles about 1-Boc-1,2,5,6-tetrahydropyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridine-3-carboxylate (125097-83-8) → 1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid (86447-11-2)

Guidance literature:

With lithium hydroxide monohydrate; water; In tetrahydrofuran; methanol; at 20 ℃; for 4h;

DOI:10.1016/j.tet.2010.05.006

Reference yield: 98.0%

1-(tert-butyl) 3-ethyl 1,2,5,6-tetrahydropyridine-1,3-dicarboxylate (126114-09-8) → 1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid (86447-11-2)

Guidance literature:

With sodium hydroxide; In methanol; water; at 20 ℃; for 15h;

DOI:10.1021/ol0066680

Reference yield: 97.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride (6027-91-4) → 1-tert-butoxycarbonyl-1,2,5,6-tetrahydropyridine-3-carboxylic acid (86447-11-2)

Guidance literature:

1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride; With triethylamine; In water; N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

di-tert-butyl dicarbonate; In water; N,N-dimethyl-formamide; at 20 ℃; for 22h;

DOI:10.1021/acs.joc.7b03171

upstream raw materials:

di-tert-butyl dicarbonate

guvacine hydrobromide

1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride

1-(tert-butyl) 3-ethyl 1,2,5,6-tetrahydropyridine-1,3-dicarboxylate

Downstream raw materials:

3-benzyl-N-t-butyloxycarbonyl-1,2,3,6-tetrahydropyridine-3-carboxylic acid

(3S)-1-(tert-butoxycarbonyl)piperidine-3-carboxylic acid

(R)-1-Boc-nipecotic acid

Refernces

• 1、 -. "IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIAL AGENTS". Page/Page column 299. . Retrieved 2020/07/14.
• 2、 -. "IMIDAZOPYRAZINE DERIVATIVES AS ANTIBACTERIALS". Page/Page column 245. . Retrieved 2020/07/14.