N-tert-Butyl-3-(((2S,6R)-4-(4-(3-cyclobutylureido)benzoyl)-2,6-dimethylpiperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Base Information

Chemical Name:N-tert-Butyl-3-(((2S,6R)-4-(4-(3-cyclobutylureido)benzoyl)-2,6-dimethylpiperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate
CAS No.:1124214-75-0
Molecular Formula:C₂HF₃O₂*C₃₀H₄₁N₅O₃
Molecular Weight:633.711
Hs Code.:

Synonyms:N-tert-Butyl-3-(((2S,6R)-4-(4-(3-cyclobutylureido)benzoyl)-2,6-dimethylpiperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-tert-Butyl-3-(((2S,6R)-4-(4-(3-cyclobutylureido)benzoyl)-2,6-dimethylpiperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

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Technology Process of N-tert-Butyl-3-(((2S,6R)-4-(4-(3-cyclobutylureido)benzoyl)-2,6-dimethylpiperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

There total 8 articles about N-tert-Butyl-3-(((2S,6R)-4-(4-(3-cyclobutylureido)benzoyl)-2,6-dimethylpiperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1124214-60-3
4-(3-cyclobutylureido)benzoic acid

: 1124214-81-8
N-tert-butyl-3-(((2S,6R)-2,6-dimethylpiperazin-1-yl)methyl)benzamide hydrochloride

: 76-05-1
trifluoroacetic acid

: 1124214-75-0
N-tert-Butyl-3-(((2S,6R)-4-(4-(3-cyclobutylureido)benzoyl)-2,6-dimethylpiperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: 4-(3-cyclobutylureido)benzoic acid; N-tert-butyl-3-(((2S,6R)-2,6-dimethylpiperazin-1-yl)methyl)benzamide hydrochloride; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: cis-2,6-dimethylpiperazine

: 1124214-75-0
N-tert-Butyl-3-(((2S,6R)-4-(4-(3-cyclobutylureido)benzoyl)-2,6-dimethylpiperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 80 °C

3: hydrogenchloride / ethanol / 2 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1094362-66-9
N-tert-butyl-3-(chloromethyl)benzamide

: 1124214-75-0
N-tert-Butyl-3-(((2S,6R)-4-(4-(3-cyclobutylureido)benzoyl)-2,6-dimethylpiperazin-1-yl)methyl)benzamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 16 h / 80 °C

2: hydrogenchloride / ethanol / 2 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 h / 20 °C

With hydrogenchloride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;