4-((4-amino-6-cyanopyrido[2,3-d]pyrimidin-7-yl)amino)benzenesulfonamide

Base Information

• Chemical Name: 4-((4-amino-6-cyanopyrido[2,3-d]pyrimidin-7-yl)amino)benzenesulfonamide
• CAS No.: 1350438-24-2
• Molecular Formula: C₁₄H₁₁N₇O₂S
• Molecular Weight: 341.353
• Mol file: 1350438-24-2.mol

Synonyms:4-((4-amino-6-cyanopyrido[2,3-d]pyrimidin-7-yl)amino)benzenesulfonamide

Chemical Property of 4-((4-amino-6-cyanopyrido[2,3-d]pyrimidin-7-yl)amino)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-((4-amino-6-cyanopyrido[2,3-d]pyrimidin-7-yl)amino)benzenesulfonamide

There total 3 articles about 4-((4-amino-6-cyanopyrido[2,3-d]pyrimidin-7-yl)amino)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-amino-7-(methylthio)pyrido[2,3-d]pyrimidine-6-carbonitrile (1350438-20-8) + sulfanilamide (63-74-1) → 4-((4-amino-6-cyanopyrido[2,3-d]pyrimidin-7-yl)amino)benzenesulfonamide (1350438-24-2)

Guidance literature:

In 1,4-dioxane; for 12h; Reflux;

DOI:10.1016/j.ejmech.2011.09.041

Reference yield:

4-amino-7-mercaptopyrido[2,3-d]pyrimidine-6-carbonitrile (1350438-18-4) → 4-((4-amino-6-cyanopyrido[2,3-d]pyrimidin-7-yl)amino)benzenesulfonamide (1350438-24-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / 0.75 h / 20 °C

2: 1,4-dioxane / 12 h / Reflux

With sodium hydroxide; In 1,4-dioxane;

DOI:10.1016/j.ejmech.2011.09.041

Reference yield:

2-amino-6-mercaptopyridine-3,5-dicarbonitrile → 4-((4-amino-6-cyanopyrido[2,3-d]pyrimidin-7-yl)amino)benzenesulfonamide (1350438-24-2)

Guidance literature:

Multi-step reaction with 3 steps

1: formic acid / 20 °C / Reflux

2: sodium hydroxide / 0.75 h / 20 °C

3: 1,4-dioxane / 12 h / Reflux

With formic acid; sodium hydroxide; In 1,4-dioxane;

DOI:10.1016/j.ejmech.2011.09.041

upstream raw materials:

4-amino-7-mercaptopyrido[2,3-d]pyrimidine-6-carbonitrile

4-amino-7-(methylthio)pyrido[2,3-d]pyrimidine-6-carbonitrile

sulfanilamide