Technology Process of Acetic acid (1R,2S,3S,4R)-2-benzyloxy-3-hydroxy-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentylmethyl ester
There total 10 articles about Acetic acid (1R,2S,3S,4R)-2-benzyloxy-3-hydroxy-4-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-cyclopentylmethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: KOH / dioxane / 1 h / Heating
3: Et3N / acetone
4: NaN3
5: toluene / 1 h / Heating
6: H2O
7: 46 percent / NaNO2 / CH2Cl2 / 24 h
8: 82 percent / MCPBA / toluene / 2 h / Heating
9: 44 percent / NaH / dimethylformamide / 48 h / 140 °C / or with K2CO3 (24 h)
With
potassium hydroxide; sodium azide; water; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium nitrite;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/S0040-4039(00)74840-4
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 65 percent / H2O2, H2SO4 / diethyl ether
2: KOH / dioxane / 1 h / Heating
4: Et3N / acetone
5: NaN3
6: toluene / 1 h / Heating
7: H2O
8: 46 percent / NaNO2 / CH2Cl2 / 24 h
9: 82 percent / MCPBA / toluene / 2 h / Heating
10: 44 percent / NaH / dimethylformamide / 48 h / 140 °C / or with K2CO3 (24 h)
With
potassium hydroxide; sodium azide; sulfuric acid; water; dihydrogen peroxide; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium nitrite;
In
1,4-dioxane; diethyl ether; dichloromethane; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/S0040-4039(00)74840-4