4-((4-chloro-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-methylbenzamide

Base Information

Chemical Name:4-((4-chloro-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-methylbenzamide
CAS No.:1236265-95-4
Molecular Formula:C₂₅H₂₉ClN₆O₃
Molecular Weight:496.997
Hs Code.:

Synonyms:4-((4-chloro-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-methylbenzamide

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Chemical Property of 4-((4-chloro-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-methylbenzamide

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Technology Process of 4-((4-chloro-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-methylbenzamide

There total 4 articles about 4-((4-chloro-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 2-(4,6-dichloro-1,3,5-triazin-2-yl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline

: 1236265-91-0
4-(aminomethyl)-N-ethyl-N-methylbenzamide TFA salt

: 1236265-95-4
4-((4-chloro-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-methylbenzamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 33233-67-9
4-(tert-Butoxycarbonylaminomethyl)benzoic acid

: 1236265-95-4
4-((4-chloro-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-methylbenzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 20 °C

1.2: 2 h / 20 °C

2.1: dichloromethane / 1 h / 20 °C

3.1: triethylamine / dichloromethane / 1 h / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.5b00138

Reference yield:

: C₁₆H₂₄N₂O₃

: 1236265-95-4
4-((4-chloro-6-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-1,3,5-triazin-2-ylamino)methyl)-N-ethyl-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 1 h / 20 °C

2: triethylamine / dichloromethane / 1 h / 20 °C

With triethylamine; In dichloromethane;
DOI:10.1021/acsmedchemlett.5b00138