1-(2-(4-bromobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

Base Information

• Chemical Name: 1-(2-(4-bromobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride
• CAS No.: 1440858-87-6
• Molecular Formula: C₁₉H₁₇BrN₂O₂*ClH
• Molecular Weight: 421.721
• Mol file: 1440858-87-6.mol

Synonyms:1-(2-(4-bromobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

Chemical Property of 1-(2-(4-bromobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2-(4-bromobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride

There total 4 articles about 1-(2-(4-bromobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1H-imidazole (288-32-4) + 1-(2-(4-bromobenzyloxy)phenyl)-3-dimethylamino-1-propanone hydrochloride (1440858-15-0) → 1-(2-(4-bromobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride (1440858-87-6)

Guidance literature:

1H-imidazole; 1-(2-(4-bromobenzyloxy)phenyl)-3-dimethylamino-1-propanone hydrochloride; In water; for 1h; Reflux;

With hydrogenchloride; In diethyl ether; isopropyl alcohol; at 20 ℃;

DOI:10.1002/ardp.201200287

Reference yield:

1-(2-(4-bromobenzyloxy)phenyl)ethanone (845866-47-9) → 1-(2-(4-bromobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride (1440858-87-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / Reflux

2.1: water / 1 h / Reflux

2.2: 20 °C

With hydrogenchloride; In water; isopropyl alcohol; 1.1: |Mannich Aminomethylation;

DOI:10.1002/ardp.201200287

Reference yield:

o-hydroxyacetophenone (118-93-4,104809-67-8) → 1-(2-(4-bromobenzyloxy)phenyl)-3-(1H-imidazol-1-yl)-1-propanone hydrochloride (1440858-87-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium ethanolate / ethanol / 0.08 h / 20 °C

1.2: 5 h / Reflux

2.1: hydrogenchloride / isopropyl alcohol; water / Reflux

3.1: water / 1 h / Reflux

3.2: 20 °C

With hydrogenchloride; sodium ethanolate; In ethanol; water; isopropyl alcohol; 2.1: |Mannich Aminomethylation;

DOI:10.1002/ardp.201200287

upstream raw materials:

1-(2-(4-bromobenzyloxy)phenyl)ethanone

o-hydroxyacetophenone

1-bromomethyl-4-bromobenzene

1H-imidazole

Downstream raw materials:

±-3-(1H-imidazol-1-yl)-1-(2'-(4-bromobenzyloxy)-phenyl)-1-propanol