2-(4-((4-(5-chlorothiophen-2-yl)-6-isopropyl-1,3,5-triazin-2-yl)amino)phenyl)acetic acid

Base Information

Chemical Name:2-(4-((4-(5-chlorothiophen-2-yl)-6-isopropyl-1,3,5-triazin-2-yl)amino)phenyl)acetic acid
CAS No.:1606973-19-6
Molecular Formula:C₁₈H₁₇ClN₄O₂S
Molecular Weight:388.878
Hs Code.:

Synonyms:2-(4-((4-(5-chlorothiophen-2-yl)-6-isopropyl-1,3,5-triazin-2-yl)amino)phenyl)acetic acid

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Chemical Property of 2-(4-((4-(5-chlorothiophen-2-yl)-6-isopropyl-1,3,5-triazin-2-yl)amino)phenyl)acetic acid

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Technology Process of 2-(4-((4-(5-chlorothiophen-2-yl)-6-isopropyl-1,3,5-triazin-2-yl)amino)phenyl)acetic acid

There total 3 articles about 2-(4-((4-(5-chlorothiophen-2-yl)-6-isopropyl-1,3,5-triazin-2-yl)amino)phenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 50478-16-5
5-chlorothiophene-2-carbonitrile

: 1606973-19-6
2-(4-((4-(5-chlorothiophen-2-yl)-6-isopropyl-1,3,5-triazin-2-yl)amino)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / methanol / 4 h / 20 °C

1.2: Inert atmosphere

2.1: trichlorophosphate / acetonitrile / 70 °C / Inert atmosphere

3.1: acetic acid / 1 h / 100 °C

With sodium methylate; acetic acid; trichlorophosphate; In methanol; acetonitrile;
DOI:10.1016/j.bmcl.2014.06.002

Reference yield:

: 1197-55-3
4-aminophenylacetic acid

: 1637216-97-7
C₁₀H₉Cl₂N₃S

: 1606973-19-6
2-(4-((4-(5-chlorothiophen-2-yl)-6-isopropyl-1,3,5-triazin-2-yl)amino)phenyl)acetic acid

Guidance literature:: With acetic acid; at 100 ℃; for 1h;
DOI:10.1016/j.bmcl.2014.06.002

Reference yield:

: 1606978-12-4
5-chloro-N-cyanothiophene-2-carboximidamide

: 1606973-19-6
2-(4-((4-(5-chlorothiophen-2-yl)-6-isopropyl-1,3,5-triazin-2-yl)amino)phenyl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: trichlorophosphate / acetonitrile / 70 °C / Inert atmosphere

2: acetic acid / 1 h / 100 °C

With acetic acid; trichlorophosphate; In acetonitrile;
DOI:10.1016/j.bmcl.2014.06.002